Document Detail


Polymorphisms of the renin-angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology.
MedLine Citation:
PMID:  17220293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The renin-angiotensin system is involved in the development of hypertension, atherosclerosis and cardiovascular disease. We studied the association between the M235T polymorphism of the angiotensinogen gene (AGT) and the C573T polymorphism of the angiotensin II type 1 receptor (AT1R) and blood pressure, carotid atherosclerosis and cerebrovascular disease.
METHODS: We genotyped over 6000 subjects from the Rotterdam Study and more than 1000 subjects from the Rotterdam Scan Study. We used logistic regression and univariate analyses, adjusting for age and sex with, for AGT, the MM and, for AT1R, the TT genotype as reference.
RESULTS: We found that AGT-235T increased systolic (p for trend = 0.03) and diastolic blood pressure (p for trend = 0.04). The prevalence of carotid plaques was increased 1.25-fold (95% CI 1.02-1.52) in AGT-TT carriers. There was a significant increase in mean volume deep subcortical white matter lesions (WML) for AGT-TT carriers (1.78 ml vs 1.09 ml in the reference group; p = 0.008). A significant interaction was found between AGT and AT1R, further increasing the effect on periventricular and subtotal WML (p for interaction = 0.02). We found a non-significant increased risk of silent brain infarction for AGT-TT carriers and AT1R-CC carriers, but no effect on stroke.
CONCLUSION: We found an association between AGT and blood pressure, atherosclerosis and WML. Also, we found synergistic effects between AGT and AT1R on the development of WML. These findings raise the question of whether the renin-angiotensin system may be a therapeutic target for the prevention of cerebral white matter pathology.
Authors:
M J E van Rijn; M J Bos; A Isaacs; M Yazdanpanah; A Arias-Vásquez; B H Ch Stricker; O H Klungel; B A Oostra; P J Koudstaal; J C Witteman; A Hofman; M M B Breteler; C M van Duijn
Related Documents :
20864943 - Early inflammatory and metabolic changes in association with agtr1 polymorphisms in pre...
11165203 - Influence of angiotensin ii type 1 receptor polymorphism on hypertension in patients wi...
2745333 - Perfused bronchial segment and bronchial strip: narrowing vs. isometric force by mediat...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-12
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  78     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-19     Completed Date:  2007-10-01     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  1083-7     Citation Subset:  IM    
Affiliation:
Department of Epidemiology and Biostatistics, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Angiotensinogen / genetics*
Carotid Artery Diseases / genetics*
Cerebrovascular Disorders / genetics*
Cohort Studies
Female
Genotype
Heterozygote
Humans
Hypertension / genetics*
Male
Polymorphism, Genetic*
Prospective Studies
Receptor, Angiotensin, Type 1 / genetics*
Renin-Angiotensin System / genetics*
Stroke / genetics
Chemical
Reg. No./Substance:
0/Receptor, Angiotensin, Type 1; 11002-13-4/Angiotensinogen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinicoradiological features of tuberculous meningitis in patients over 50 years of age.
Next Document:  The risk of recurrent stroke after intracerebral haemorrhage.