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Polymorphisms of the methylenetetrahydrofolate reductase, vascular endothelial growth factor, endothelial nitric oxide synthase, monocyte chemoattractant protein-1 and apolipoprotein E genes are not associated with carotid intima-media thickness.
MedLine Citation:
PMID:  19148342     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Single nucleotide polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR), vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), monocyte chemoattractant protein-1 (MCP-1) and apolipoprotein E (ApoE) genes appear to be a genetic risk factor for atherosclerosis. Common carotid intima-media thickness (cIMT) provides information on the severity of atherosclerosis.
OBJECTIVE: To investigate the relationship between cIMT and gene polymorphisms associated with atherosclerosis in Turkish patients with coronary artery disease (CAD).
METHODS: Sixty-two patients with angiographically diagnosed stable CAD were divided into two groups according to their cIMT values (group 1: n=35, cIMT of 1 mm or greater; group 2: n=27, cIMT of less than 1 mm). MTHFR 677 C/T, VEGF --460 C/T, eNOS 894 G/T, MCP-1 --2518 A/G and ApoE (E2, E3 and E4) gene polymorphisms (where A is adenine, C is cytosine, G is guanine and T is thymine) were analyzed by polymerase chain reaction and restriction fragment length polymorphism. Evaluations of cardiovascular risk factors and coronary atherosclerotic lesions were performed in all patients. Serum homocysteine and high-sensitivity C-reactive protein were measured and compared between the two groups.
RESULTS: Serum high-sensitivity C-reactive protein (P=0.04) and homocysteine (P=0.006) levels were higher in group 1 than in group 2. The ratio of multivessel CAD and previous myocardial infarction was significantly higher in group 1 than in group 2 (P=0.014). In the study population, no significant difference in cIMT was observed according to the polymorphisms studied. Only hyperhomocysteinemia (OR 1.17 [95% CI 1.01 to 1.35], P=0.033) and previous myocardial infarction (OR 3.76 [95% CI 1.10 to 12.81], P=0.034) maintained a significant correlation with cIMT on multiple logistic regression analysis.
CONCLUSION: cIMT is increased in patients with hyperhomocysteinemia, inflammation and extended CAD. MTHFR 677 C/T, VEGF --460 C/T, eNOS 894 G/T, MCP-1 --2518 A/G and ApoE single nucleotide polymorphisms were not associated with increased cIMT.
Authors:
Emin Alioglu; Ugur Turk; Sirri Cam; Abbasali Abbasaliyev; Istemihan Tengiz; Ertugrul Ercan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  25     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-03-03     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  e1-5     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Central Hospital, Bayrakli, Izmir, Turkey. dreminalioglu@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Apolipoproteins E / genetics*
C-Reactive Protein / analysis
Carotid Artery, Common / pathology*
Chemokine CCL2 / genetics*
Coronary Artery Disease / blood,  genetics*,  pathology
Homocysteine / blood
Humans
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Nitric Oxide Synthase Type III / genetics*
Polymorphism, Single Nucleotide*
Tunica Intima / pathology
Tunica Media / pathology
Vascular Endothelial Growth Factor A / genetics*
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Chemokine CCL2; 0/Vascular Endothelial Growth Factor A; 454-28-4/Homocysteine; 9007-41-4/C-Reactive Protein; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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