| Polymorphisms in tumour necrosis factor alpha, interleukin-10 and transforming growth factor beta1 genes and end-stage liver disease. | |
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MedLine Citation:
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PMID: 11192323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine any relationship between polymorphisms in the genes encoding tumour necrosis factor alpha (TNFalpha), interleukin-10 (IL-10) and transforming growth factor beta1 (TGFbeta1) and end-stage liver disease. METHODS: Whole-blood samples were taken from patients attending the Scottish Liver Transplant Unit with end-stage liver disease (primary biliary cirrhosis, n = 61; alcoholic liver disease, n = 25; primary sclerosing cholangitis, n = 17; viral disease, n = 8; type 1 auto-immune hepatitis, n = 8; acute liver failure, n = 20). DNA was extracted and the polymorphisms at positions TNF -308, IL-10 -1082 and TGFbeta1 +869 and +915 were determined using sequence-specific oligonucleotide probes. Samples were also analysed from normal healthy controls. RESULTS: There was a significant difference between patients with primary sclerosing cholangitis and healthy controls, with 65% of patients (11/17) possessing at least one TNF2 allele (A at position -308) compared with 38% of controls (P = 0.02). Four of the eight patients with auto-immune hepatitis were homozygous for TNF2 while the other four were heterozygous (P = 0.001). No significant difference between controls and patients was seen in polymorphisms for IL-10 or TGFbeta1. No association between genotype and Child's class was found in primary biliary cirrhosis. CONCLUSION: Patients with primary sclerosing cholangitis and auto-immune hepatitis are more likely to possess TNF2 than normal controls. This allele has been associated with an increased production of TNFalpha in vitro and may indicate a predisposition to these inflammatory conditions. |
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Authors:
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A J Bathgate; V Pravica; C Perrey; P C Hayes; I V Hutchinson |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: European journal of gastroenterology & hepatology Volume: 12 ISSN: 0954-691X ISO Abbreviation: Eur J Gastroenterol Hepatol Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-15 Completed Date: 2001-04-05 Revised Date: 2009-10-16 |
Medline Journal Info:
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Nlm Unique ID: 9000874 Medline TA: Eur J Gastroenterol Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 1329-33 Citation Subset: IM |
Affiliation:
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Department of Medicine, Royal Infirmary of Edinburgh, UK. abathgate@ed.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Genetic Markers Humans Interleukin-10 / analysis, genetics* Liver Failure / genetics*, surgery Liver Transplantation Male Middle Aged Polymorphism, Genetic* Probability Reference Values Sensitivity and Specificity Severity of Illness Index Transforming Growth Factor beta / analysis, genetics* Tumor Necrosis Factor-alpha / analysis, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; 0/Transforming Growth Factor beta; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10 |
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