Document Detail


Polymorphisms in the leptin receptor gene, body composition and fat distribution in overweight and obese women.
MedLine Citation:
PMID:  11360155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Leptin is an adipocyte-secreted hormone involved in body weight regulation, acting through the leptin receptor, localised centrally in the hypothalamus as well as peripherally, amongst others on adipose tissue. The aim of this study was to evaluate whether polymorphisms in the leptin receptor (LEPR) gene were related to obesity and body fat distribution phenotypes, such as waist and hip circumferences and the amount of visceral and subcutaneous fat. METHODS: Three known LEPR polymorphisms, Lys109Arg, Gln223Arg and Lys656Asn, were typed on genomic DNA of 280 overweight and obese women (body mass index (BMI)>25), aged 18-60 y. General linear model (GLM) analyses were performed in 198 pre- and 82 postmenopausal women, adjusting the data for age and menopausal state, plus fat mass for the fat distribution phenotypes. RESULTS: No associations were found between the LEPR polymorphisms and BMI or fat mass. In postmenopausal women, carriers of the Asn656 allele had increased hip circumference (P=0.03), total abdominal fat (P=0.03) and subcutaneous fat (P=0.04) measured by CT scan. Total abdominal fat was also higher in Gln223Gln homozygotes (P=0.04). Also in postmenopausal women, leptin levels were higher in Lys109Lys homozygotes (P=0.02). CONCLUSION: In conclusion, polymorphisms in the leptin receptor gene are associated with levels of abdominal fat in postmenopausal overweight women. Since body fat distribution variables were adjusted for fat mass, these results suggest that DNA sequence variations in the leptin receptor gene play a role in fat topography and may be involved in the predisposition to abdominal obesity.
Authors:
M Wauters; I Mertens; M Chagnon; T Rankinen; R V Considine; Y C Chagnon; L F Van Gaal; C Bouchard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  25     ISSN:  0307-0565     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-21     Completed Date:  2001-12-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  714-20     Citation Subset:  IM    
Affiliation:
Department of Endocrinology, Metabolism and Clinical Nutrition, University Hospital Antwerp, Antwerp, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / anatomy & histology*
Adolescent
Adult
Alleles
Body Composition*
Body Mass Index
Carrier Proteins / genetics*
European Continental Ancestry Group / genetics
Female
Humans
Leptin / genetics
Menopause
Middle Aged
Obesity / genetics*
Phenotype
Polymorphism, Genetic*
Receptors, Cell Surface*
Receptors, Leptin
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Leptin; 0/Receptors, Cell Surface; 0/Receptors, Leptin; 0/leptin receptor, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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