| Polymorphisms in the human CC chemokine receptor-3 gene. | |
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MedLine Citation:
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PMID: 9804946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CC chemokine receptor (CCR)-3 is a seven-transmembrane-spanning G-protein-coupled receptor (GPCR) that is involved in the recruitment of inflammatory cells in allergic responses and acts as a co-receptor for entry of HIV into cells. Selected polymorphisms in GPCRs have been shown to have dramatic effects on the manifestation and/or susceptibility to a variety of diseases. In this report, we tested whether the human CCR-3 gene locus is genetically polymorphic. Using single-stranded conformational polymorphism analysis of genomic DNA, the CCR-3 gene is shown to contain four nucleotide polymorphisms with allele frequencies ranging from 0.005 to 0.13. Two polymorphisms encode for an amino acid change. One of these polymorphisms encodes for a non-conservative change of arginine to glutamine at position 275 of the third extracellular loop. Stratification of the DNA samples into a population with asthma suggested no change in this allele's frequency. Another polymorphism encodes for a leucine to proline substitution in the intracellular cytoplasmic tail of CCR-3. The most frequent polymorphism, T51C, occurs in 26% of individuals and encodes for a silent substitution. Thus, CCR-3 contains several genetic variations which may have consequences in disease processes that involve this receptor. |
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Authors:
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N Zimmermann; J A Bernstein; M E Rothenberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1442 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1998-12-17 Completed Date: 1998-12-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 170-6 Citation Subset: IM; X |
Affiliation:
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Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult African Continental Ancestry Group / genetics Aged Aged, 80 and over Amino Acid Sequence Asthma / genetics, immunology Base Sequence Child DNA Primers European Continental Ancestry Group / genetics HIV / physiology Humans Infant, Newborn Models, Molecular Molecular Sequence Data Ohio Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Polymorphism, Single-Stranded Conformational* Protein Structure, Secondary Receptors, CCR3 Receptors, Chemokine / chemistry*, genetics* Receptors, HIV / chemistry, genetics |
| Chemical | |
Reg. No./Substance:
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0/CCR3 protein, human; 0/DNA Primers; 0/Receptors, CCR3; 0/Receptors, Chemokine; 0/Receptors, HIV |
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