Document Detail


Polymorphisms in NLRP1 gene and susceptibility to autoimmune thyroid disease.
MedLine Citation:
PMID:  23374100     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The autoimmune thyroid disorders, or AITDs, comprise 2 related disorders, Graves'disease and Hashimoto thyroiditis. In AITD, immune system produces antibodies against autothyroid antigens. The etiology of AITDs involves a complex interaction between genetic predisposing factors and environmental triggering factors. Variations inNACHT leucine-rich repeat protein 1(NLRP1) gene a key regulator of the innate immunity have been shown to confer risk for vitiligo and several autoimmune diseases. In this study we hypothesizethatvariants in NLRP1 genemight be involved in the susceptibility to autoimmune thyroid disease. Five single nucleotide polymorphisms (SNPs) in NLRP1 were genotyped in 207 AITD patients and 220 normal controls. We found that NLRP1 rs12150220 T allele (OR=1.273, 95% CI: 0.971-1.670, p=0.040) and NLRP1 rs2670660 G allele (OR=1.264, 95% CI: 0.965-1.656, p=0.044) were significantly associated with AITD compared with controls. These results suggest that NLRP1 may be involved in the pathogenesis of AITD.
Authors:
Asem Alkhateeb; Yousef Jarun; Reema Tashtoush
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-4
Journal Detail:
Title:  Autoimmunity     Volume:  -     ISSN:  1607-842X     ISO Abbreviation:  Autoimmunity     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900070     Medline TA:  Autoimmunity     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Genetics and Biotechnology, Jordan University of Science and Technology , Irbid , Jordan.
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