Document Detail


Polymorphisms in the N-methyl-D-aspartate receptor 1 and 2B subunits are associated with alcoholism-related traits.
MedLine Citation:
PMID:  14573320     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: This study examined the hypothesis that allelic variants of the ionotropic glutamatergic N-methyl-D-aspartate receptor (NMDAR) are associated with vulnerability to alcoholism and some related traits.
METHODS: We investigated the silent G2108A and C2664T polymorphisms of the NMDAR1 and the NMDAR2B genes, respectively. The case control study included 367 alcoholic and 335 control subjects of German origin. The family-based study comprised 81 Polish alcoholic patients and their parents using the transmission disequilibrium test.
RESULTS: The genotype frequencies of the NMDAR1 polymorphism differed significantly between control and alcoholic subjects. This difference was also observed in more homogenous subgroups of alcoholic subjects with vegetative withdrawal syndrome and Cloninger type 1. Patients with a history of delirium tremens or seizures during withdrawal showed a significantly increased prevalence of the A allele. Genotyping of the NMDAR2B polymorphism revealed a significantly reduced T allele in Cloninger type 2 alcoholics and in patients reporting an early onset compared with control subjects. Our family-based study for NMDAR2B, revealed a trend to a preferred transmission of the C allele by the fathers, and families with early-onset patients contributed most to this trend.
CONCLUSIONS: These results suggest that variants in NMDAR genes are associated with alcoholism and related traits.
Authors:
Catrin Wernicke; Jerzy Samochowiec; Lutz G Schmidt; Georg Winterer; Michael Smolka; Jolanta Kucharska-Mazur; Jan Horodnicki; Jürgen Gallinat; Hans Rommelspacher
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological psychiatry     Volume:  54     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-23     Completed Date:  2003-11-21     Revised Date:  2013-02-13    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  922-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Neurobiology, University Hospital Benjamin Franklin, Free University of Berlin, Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcoholism / genetics*
Alleles
Case-Control Studies
Female
Gene Frequency
Genotype
Humans
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length
Receptors, N-Methyl-D-Aspartate / genetics*
Chemical
Reg. No./Substance:
0/NMDA receptor A1; 0/NR2B NMDA receptor; 0/Receptors, N-Methyl-D-Aspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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