Document Detail

Polymorphisms in the HBB gene relate to individual cardiorespiratory adaptation in response to endurance training.
MedLine Citation:
PMID:  16990440     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The crucial role of haemoglobin in endurance performance has been well documented. We examined whether polymorphisms in the HBB gene modified aerobic capacity.
METHODS: 102 recruits were trained by running 5000 m three times per week for 18 weeks. Exercise intensity progressively increased from an initial heart rate corresponding to 95% of the individual baseline ventilatory threshold during the first 10 weeks to 105% during the last 8 weeks. The phenotypes measured were running economy and VO(2)max. Running economy was determined by measuring submaximal VO(2) for 5 min at a constant running speed of 12 km.h(-1) and VO(2)max was obtained during an incremental test to exhaustion. Genomic DNA was extracted from white cells of peripheral blood and the -551C/T, intron2,+16C/G and +340 A/T genotypes were examined relative to the TAA site variants by PCR-RFLP.
RESULTS: Genotype distributions were in Hardy-Weinberg equilibrium at three loci. None of the running economy and VO(2)max-related traits were associated with the three polymorphisms or haplotypes at baseline, while the training response of running economy was associated with -551C/T and intron2,+16C/G polymorphisms. Subjects homozygous for intron2,+16C/C or -551C/C had decreased oxygen cost of running compared to the other individuals.
DISCUSSION: It was concluded that the -551C/C or intron2,+16C/C genotype might explain part of the individual variation in the cardiorespiratory adaptation to endurance training.
Z He; Y Hu; L Feng; Y Lu; G Liu; Y Xi; L Wen; X Xu; K Xu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-21
Journal Detail:
Title:  British journal of sports medicine     Volume:  40     ISSN:  1473-0480     ISO Abbreviation:  Br J Sports Med     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-24     Completed Date:  2007-01-11     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0432520     Medline TA:  Br J Sports Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  998-1002     Citation Subset:  IM    
Biology Center, China Institute of Sport Science, Beijing, China.
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MeSH Terms
Adaptation, Physiological / genetics*,  physiology
Hemoglobins / genetics*
Oxygen Consumption / genetics*,  physiology
Physical Education and Training / methods
Physical Endurance / genetics*,  physiology
Polymorphism, Genetic / genetics,  physiology
Running / physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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