| Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer: a genetic association study and meta-analysis. | |
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MedLine Citation:
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PMID: 20720556 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The endothelial nitric oxide synthase gene (NOS3) has been proposed as a candidate gene for breast cancer (BC), however, the specific role of variants and haplotypes has not been clarified. We examined the association of two polymorphisms (4b/a and G894T) and their haplotypes in a case-control sample of 306 patients with BC and in 131 healthy females. In addition, a meta-analysis of studies investigating association between NOS3 polymorphisms and BC was conducted. The single locus analysis for the two polymorphisms revealed an association only for the 4b/a polymorphism, but adjustment for age diminished this association (odds ratio (OR) (95% confidence interval)=0.98 (0.34-2.81)). The analysis of haplotypes showed an association for two haplotypes involving the 894T allele (bT and aT) (P<0.05). The meta-analysis for both polymorphisms produced nonsignificant associations without significant heterogeneity. A positive association was detected for the promoter T786C polymorphism (pooled OR=1.51 (1.07-2.12)), but this comparison was based on few studies. The available evidence from our study and the meta-analysis cannot support a major contributory role of these common NOS3 polymorphisms in BC, although future larger studies may help in drawing safer conclusions about the genetics of BC. |
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Authors:
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Elias Zintzaras; Maria Grammatikou; Georgios D Kitsios; Chrysa Doxani; Nikos Zdoukopoulos; Christos Papandreou; Anna Patrikidou |
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Publication Detail:
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Type: Journal Article Date: 2010-08-19 |
Journal Detail:
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Title: Journal of human genetics Volume: 55 ISSN: 1435-232X ISO Abbreviation: J. Hum. Genet. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9808008 Medline TA: J Hum Genet Country: Japan |
Other Details:
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Languages: eng Pagination: 743-8 Citation Subset: IM |
Affiliation:
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Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece. |
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Erratum In:
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J Hum Genet. 2010 Nov;55(11):777 Note: Patrikidou, Anna [added] |
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