Document Detail


Polymorphisms of the angiotensin converting enzyme gene in relation to intrauterine growth restriction.
MedLine Citation:
PMID:  20524904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this case-control study was to explore the relation between maternal and infant angiotensin converting enzyme (ACE) activity and its genotypes in uncomplicated term pregnancies (> or =37 weeks) and pregnancies with growth-restricted infants (birthweight at or below the 5th centile). Venous cord bloods and maternal venous samples were obtained for serum ACE activity and ACE genotype. Growth-restricted infants (< or =5th centile) were more likely to be of the DD genotype compared to appropriately grown infants (42 vs. 13%, p = 0.003). There was no significant difference in the frequency of the maternal DD genotype between the two groups (33 vs. 22%, p = 0.43) and similarly no significant differences in the maternal or fetal ACE activities. Within the intrauterine growth restriction (IUGR) group, infants of the DD genotype had higher ACE activity compared to appropriately grown infants (p = 0.03). In conclusion, the DD genotype of the ACE gene appears to be associated with fetal growth and may be a factor in the increased risk of adult onset chronic diseases among growth-restricted infants.
Authors:
Ramalingam Uma; J Stewart Forsyth; Allan D Struthers; Callum G Fraser; Valerie Godfrey; Deirdre J Murphy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  89     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-31     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  1197-201     Citation Subset:  IM    
Affiliation:
University of Dundee, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Gas Analysis
Case-Control Studies
Female
Fetal Blood
Fetal Growth Retardation / genetics*
Gene Frequency
Genotype
Homozygote
Humans
Hydrogen-Ion Concentration
Peptidyl-Dipeptidase A / blood,  genetics*
Polymorphism, Genetic*
Pregnancy
Sequence Deletion
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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