Document Detail


Polymorphisms of renin-angiotensin system and natriuretic peptide receptor A genes in patients of Greek origin with a history of myocardial infarction.
MedLine Citation:
PMID:  20529973     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed the association between (CA)n repeat polymorphism of angiotensinogen (AGT), 250 base pair (bp) insertion/deletion (I/D) of angiotensin-converting enzyme (ACE), tetranucleotide repeat polymorphism (TCTG)n of renin (REN), (CT)n repeat polymorphism of the natriuretic peptide receptor A (NPRA) genes, and the presence and extent of coronary artery disease (CAD) in Greek patients with a history of myocardial infarction (MI). A total of 158 post-MI patients referred for coronary angiography were compared with 144 controls. The SS genotype of the AGT gene was related with an increased risk for 3-vessel CAD (odds ratio [OR], 1.94; 95% confidence interval [CI], 1.05-3.61; P = .041), whereas the SL genotype was related with a decreased risk (OR, 0.44; 95% CI, 0.22-0.87; P = .019). Moreover, there was a trend for the SL genotype of the REN gene toward increased risk for CAD. There was a significant association between (CA)n polymorphism of the AGT gene and the extent of CAD in Greek patients with a history of MI.
Authors:
George Karayannis; Aspasia Tsezou; Eirini Giannatou; Vassilios Papanikolaou; Gregory Giamouzis; Filippos Triposkiadis
Publication Detail:
Type:  Journal Article     Date:  2010-06-07
Journal Detail:
Title:  Angiology     Volume:  61     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2010-11-01     Revised Date:  2010-12-21    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  737-43     Citation Subset:  IM    
Affiliation:
Department of Cardiology, University Hospital of Larissa, Larissa, Greece. geokaragian@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Angiotensinogen / genetics*
Coronary Artery Disease / genetics
Female
Greece
Humans
Male
Myocardial Infarction / genetics*
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic*
Receptors, Atrial Natriuretic Factor / genetics*
Renin / genetics*
Chemical
Reg. No./Substance:
11002-13-4/Angiotensinogen; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.23.15/Renin; EC 4.6.1.2/Receptors, Atrial Natriuretic Factor; EC 4.6.1.2/atrial natriuretic factor receptor A
Comments/Corrections
Comment In:
Angiology. 2011 Jan;62(1):5-6   [PMID:  21134991 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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