Document Detail

Polymorphisms of renin-angiotensin system and natriuretic peptide receptor A genes in patients of Greek origin with a history of myocardial infarction.
MedLine Citation:
PMID:  20529973     Owner:  NLM     Status:  MEDLINE    
We assessed the association between (CA)n repeat polymorphism of angiotensinogen (AGT), 250 base pair (bp) insertion/deletion (I/D) of angiotensin-converting enzyme (ACE), tetranucleotide repeat polymorphism (TCTG)n of renin (REN), (CT)n repeat polymorphism of the natriuretic peptide receptor A (NPRA) genes, and the presence and extent of coronary artery disease (CAD) in Greek patients with a history of myocardial infarction (MI). A total of 158 post-MI patients referred for coronary angiography were compared with 144 controls. The SS genotype of the AGT gene was related with an increased risk for 3-vessel CAD (odds ratio [OR], 1.94; 95% confidence interval [CI], 1.05-3.61; P = .041), whereas the SL genotype was related with a decreased risk (OR, 0.44; 95% CI, 0.22-0.87; P = .019). Moreover, there was a trend for the SL genotype of the REN gene toward increased risk for CAD. There was a significant association between (CA)n polymorphism of the AGT gene and the extent of CAD in Greek patients with a history of MI.
George Karayannis; Aspasia Tsezou; Eirini Giannatou; Vassilios Papanikolaou; Gregory Giamouzis; Filippos Triposkiadis
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Publication Detail:
Type:  Journal Article     Date:  2010-06-07
Journal Detail:
Title:  Angiology     Volume:  61     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2010-11-01     Revised Date:  2010-12-21    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  737-43     Citation Subset:  IM    
Department of Cardiology, University Hospital of Larissa, Larissa, Greece.
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MeSH Terms
Angiotensinogen / genetics*
Coronary Artery Disease / genetics
Myocardial Infarction / genetics*
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic*
Receptors, Atrial Natriuretic Factor / genetics*
Renin / genetics*
Reg. No./Substance:
11002-13-4/Angiotensinogen; EC A; EC; EC, Atrial Natriuretic Factor; EC natriuretic factor receptor A
Comment In:
Angiology. 2011 Jan;62(1):5-6   [PMID:  21134991 ]

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