| Polymorphisms of renin-angiotensin system and natriuretic peptide receptor A genes in patients of Greek origin with a history of myocardial infarction. | |
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MedLine Citation:
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PMID: 20529973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We assessed the association between (CA)n repeat polymorphism of angiotensinogen (AGT), 250 base pair (bp) insertion/deletion (I/D) of angiotensin-converting enzyme (ACE), tetranucleotide repeat polymorphism (TCTG)n of renin (REN), (CT)n repeat polymorphism of the natriuretic peptide receptor A (NPRA) genes, and the presence and extent of coronary artery disease (CAD) in Greek patients with a history of myocardial infarction (MI). A total of 158 post-MI patients referred for coronary angiography were compared with 144 controls. The SS genotype of the AGT gene was related with an increased risk for 3-vessel CAD (odds ratio [OR], 1.94; 95% confidence interval [CI], 1.05-3.61; P = .041), whereas the SL genotype was related with a decreased risk (OR, 0.44; 95% CI, 0.22-0.87; P = .019). Moreover, there was a trend for the SL genotype of the REN gene toward increased risk for CAD. There was a significant association between (CA)n polymorphism of the AGT gene and the extent of CAD in Greek patients with a history of MI. |
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Authors:
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George Karayannis; Aspasia Tsezou; Eirini Giannatou; Vassilios Papanikolaou; Gregory Giamouzis; Filippos Triposkiadis |
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Publication Detail:
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Type: Journal Article Date: 2010-06-07 |
Journal Detail:
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Title: Angiology Volume: 61 ISSN: 1940-1574 ISO Abbreviation: Angiology Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-15 Completed Date: 2010-11-01 Revised Date: 2010-12-21 |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 737-43 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University Hospital of Larissa, Larissa, Greece. geokaragian@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiotensinogen / genetics* Coronary Artery Disease / genetics Female Greece Humans Male Myocardial Infarction / genetics* Peptidyl-Dipeptidase A / genetics* Polymorphism, Genetic* Receptors, Atrial Natriuretic Factor / genetics* Renin / genetics* |
| Chemical | |
Reg. No./Substance:
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11002-13-4/Angiotensinogen; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.23.15/Renin; EC 4.6.1.2/Receptors, Atrial Natriuretic Factor; EC 4.6.1.2/atrial natriuretic factor receptor A |
| Comments/Corrections | |
Comment In:
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Angiology. 2011 Jan;62(1):5-6
[PMID:
21134991
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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