Document Detail


Polymorphisms of human nonmetastatic clone 23 type 1 gene and neoplastic lesions of uterine cervix.
MedLine Citation:
PMID:  20601538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HYPOTHESIS: Single-nucleotide polymorphisms (SNP) in promoter of human nonmetastatic clone 23 type 1 (nm23-H1) may affect their binding with transcription factors and affect promoter activity as well as gene transcription. Therefore, we investigated the impact of the nm23-H1 gene polymorphisms on the neoplastic lesions of uterine cervix in mid-Taiwan women (women who live in the central area of Taiwan). We expected that women with different genotypes in nm23-H1 polymorphisms, such as rs34214448, rs16949649, or rs2302254, may have different incidences of cervical neoplasia.
MATERIALS AND METHODS: In total, 366 blood samples were collected from 244 healthy women and 122 patients with cervical neoplasia to analyze 3 nm23-H1 gene single-nucleotide polymorphisms (rs34214448, rs16949649, and rs2302254).
RESULTS: The heterozygous genotypes, TG in rs34214448 or TC in rs16949649, were differentially distributed between patients with cervical neoplasia and normal women (Hommel adjusted P = .0440 and .0435, respectively) as compared to their homozygotes. Moreover, compared to those with wild-type homozygotes and heterozygotes, women with variant homozygotes TT in rs34214448 or CC in rs16949649 exert different distributions between patients with cervical neoplasia and normal women (P = .058 and .058). Interestingly, we found the genotype distribution of rs34214448 has significant association with that of rs16949649 with high consistency.
CONCLUSIONS: Mid-Taiwan women with the polymorphic heterozygotes TG in rs34214448 or TC in rs16949649 of human nonmetastatic clone 23 type 1 promoter have the tendency to develop cervical neoplasia while compared to their homozygous counterparts. However, women with variant homozygotes TT in rs34214448 or CC in rs16949649 exhibit less tendency as compared to those with wild-type homozygotes and heterozygotes.
Authors:
Chi-Yen Feng; Po-Hui Wang; Hsiu-Ting Tsai; Yi-Torng Tee; Jiunn-Liang Ko; Shiuan-Chih Chen; Ching-Yi Lin; Chih-Ping Han; Jia-Sin Yang; Yu-Fan Liu; Long-Yau Lin; Shun-Fa Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-02
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  17     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-21     Completed Date:  2010-12-30     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  886-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chi-Square Distribution
DNA, Neoplasm / chemistry,  genetics
Female
Genetic Variation / genetics*
Genotype
Humans
Middle Aged
NM23 Nucleoside Diphosphate Kinases / genetics*
Polymerase Chain Reaction
Polymorphism, Single Nucleotide / genetics*
Taiwan
Uterine Cervical Neoplasms / genetics*
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/NM23 Nucleoside Diphosphate Kinases; EC 2.7.4.6/NME1 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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