Document Detail

Polymorphisms of EDNRB, ATG, and ACE genes in salt-sensitive hypertension.
MedLine Citation:
PMID:  18758497     Owner:  NLM     Status:  MEDLINE    
Almost 50% of hypertensive individuals manifest blood pressure changes in response to salt depletion or repletion and are termed "salt sensitive" (SS). Blunted activity of the endothelin (ET) system and the renin-angiotensin-aldosterone system (RAAS) have been reported as possible mechanisms contributing to salt sensitivity. Data are available that endothelin receptor subtype B (ETBR)-deficient rats develop salt-sensitive hypertension when fed a high-salt diet. Whether the ETBR gene (EDNRB) is involved in genetic predisposition to human salt-sensitive hypertension has not been studied so far. We screened EDNRB in 104 hypertensive patients (49 salt sensitive and 55 salt resistant) and 110 normotensive controls. No new sequence variation was found, but genotype distribution of the common polymorphism G1065A revealed that the AA + GA genotypes were significantly more frequent in salt-resistant than in salt-sensitive individuals (p = 0.007), suggesting a protective role for the A allele. We also screened angiotensinogen gene AGT M235T and angiotensin-converting enzyme insertion/deletion polymorphism ACE I/D and found an association between TT genotype and hypertension. A possible synergistic effect to salt-sensitive hypertension was found by combining EDNRB GG with ACE DD/ID genotypes. In conclusion, our data confirm the role of ET system and RAAS in salt-sensitive hypertension.
Jessica Caprioli; Caterina Mele; Chiara Mossali; Laura Gallizioli; Gilberta Giacchetti; Marina Noris; Giuseppe Remuzzi; Ariela Benigni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  86     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-09-04     Completed Date:  2008-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  505-10     Citation Subset:  IM    
Clinical Research Center for Rare Diseases Aldo e Cele Daccò, Mario Negri Institute for Pharmacological Research, Via Camozzi 3, Ranica, Bergamo, Italy.
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MeSH Terms
Angiotensinogen / genetics*
DNA Primers
Exons / genetics
Hypertension / chemically induced*,  genetics*
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic / genetics
RNA, Messenger / biosynthesis,  genetics
Receptor, Endothelin B / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Sodium Chloride*
Reg. No./Substance:
0/DNA Primers; 0/RNA, Messenger; 0/Receptor, Endothelin B; 11002-13-4/Angiotensinogen; 7647-14-5/Sodium Chloride; EC A

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