Document Detail


Polymorphisms of Ag-stained nucleolar organizer regions in man.
MedLine Citation:
PMID:  7201973     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polymorphisms of the NORs as tested by Ag-staining of metaphase G-banded chromosomes were investigated in cultured blood lymphocytes of karyotypically normal individuals from the Moscow population. The study of cell-to-cell variability in the number of Ag-stained NORs carried out on 14 monozygotic twin pairs showed the phenomenon to have some features of real intercellular variation. In 40 unrelated individuals the individual acrocentric chromosomes were compared by the number of Ag-stained NORs, their degree of staining, and their participation in acrocentric association. Chromosome 21 was found to be significantly more active than four others by all the criteria, and chromosome 15 was less active compared with the others by the size of the Ag deposits and the frequency of participation in NOR associations. The frequency distribution of homozygotes and heterozygotes for Ag-stained NORs in the same group of 40 individuals was in accordance with the Hardy-Weinberg law.
Authors:
A F Zakharov; A Z Davudov; V A Benjush; N A Egolina
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  60     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1982  
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  334-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Azure Stains
Chromosome Banding
Chromosomes, Human, 13-15 / ultrastructure*
Chromosomes, Human, 21-22 and Y / ultrastructure*
Female
Genetic Variation
Heterozygote
Homozygote
Humans
Lymphocytes / ultrastructure
Male
Metaphase
Nucleolus Organizer Region / analysis*
Polymorphism, Genetic*
Pregnancy
Silver Nitrate
Twins, Monozygotic
Chemical
Reg. No./Substance:
0/Azure Stains; 7761-88-8/Silver Nitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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