Document Detail

Polymorphism in the interleukin-1 gene complex and spontaneous preterm delivery.
MedLine Citation:
PMID:  12114904     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We examined the association between preterm delivery and polymorphisms at position +3953 of the interleukin-1 beta gene (IL1B+3953) and in intron 2 of the interleukin-1 receptor antagonist gene (IL1RN). STUDY DESIGN: This was a case-control study that involved 52 pregnancies that resulted in spontaneous preterm delivery before 34 weeks of gestation and 197 pregnancies that resulted in birth at term. Polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism analysis. RESULTS: Homozygous carriage of IL1B+3953 allele 1 by fetuses of African descent was associated with a risk of preterm delivery (P =.033). Fetuses of Hispanic descent that carried IL1RN allele 2 were found to be at an increased risk for preterm premature rupture of membranes and subsequent preterm delivery(P =.021; odds ratio, 6.5; 95% CI, 1.25-37.7). CONCLUSION: There are associations of spontaneous preterm delivery with the fetal carriage of IL1B+3953*1 and IL1RN*2 alleles in African and Hispanic populations, respectively.
Mehmet R Genç; Stefan Gerber; Mirjana Nesin; Steven S Witkin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  187     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-12     Completed Date:  2002-08-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-63     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, USA.
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MeSH Terms
African Continental Ancestry Group / genetics
Case-Control Studies
Chromosomes, Human, Pair 2
Fetal Membranes, Premature Rupture / ethnology,  genetics*
Hispanic Americans / genetics
Interleukin-1 / genetics*
Obstetric Labor, Premature / ethnology,  genetics*
Polymerase Chain Reaction
Polymorphism, Genetic*
Receptors, Interleukin-1 / antagonists & inhibitors*
Grant Support
Reg. No./Substance:
0/Interleukin-1; 0/Receptors, Interleukin-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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