Document Detail


Polymorphism in the gelatinase B gene and the severity of coronary arterial stenosis.
MedLine Citation:
PMID:  11410119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gelatinase B, as one of the matrix metalloproteinases, may be relevant to atherogenic plaque development and stability. Recently, a C-1562T substitution in the regulatory region of the gelatinase B gene was shown to up-regulate gelatinase B expression, which could be relevant to both the severity and stability of atherosclerotic plaques. We determined the genotype of 788 angiographically documented Caucasian patients with coronary artery disease (583 males and 205 females; age 56.7+/-0.4 years). The proportions of C/C (77.1%), C/T (21.4%) and T/T (1.5%) genotypes were in Hardy-Weinberg equilibrium, and did not differ between males and females (P>0.05). The frequencies of the rare T allele in patients with angiographically documented coronary artery disease (0.123), a past history of myocardial infarction (0.128) or unstable angina (0.128) were not significantly different from those in patients without such events (0.121, 0.118 and 0.128 respectively; P>0.05). In addition, the rare allele frequencies among patients with no (0.128), one (0.124), two (0.108) or three (0.121) significantly diseased vessels (> or =50% luminal obstruction) were not statistically different (P=0.932). However, the male rare T/T homozygotes had lower waist/hip ratios and levels of high-density lipoprotein cholesterol (HDL-C), and higher total cholesterol/HDL-C ratios, than C/C homozygotes (P<0.05). In conclusion, our study in a large series of angiographically defined patients suggests that the C-1562T polymorphism may not be useful as a predictor of the presence and severity of coronary atherosclerosis.
Authors:
J Wang; D Warzecha; D Wilcken; X L Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  101     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-18     Completed Date:  2001-08-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
Affiliation:
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227-5301, U.S.A.
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MeSH Terms
Descriptor/Qualifier:
Angina, Unstable / blood,  genetics
Body Constitution / genetics
Chi-Square Distribution
Cholesterol, HDL / blood
Coronary Artery Disease / blood,  genetics*
Female
Gene Frequency / genetics
Genetics, Population
Genotype
Homozygote
Humans
Logistic Models
Male
Matrix Metalloproteinase 9 / genetics*
Middle Aged
Myocardial Infarction / blood,  genetics
New South Wales
Polymorphism, Genetic*
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; EC 3.4.24.35/Matrix Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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