Document Detail

Polymorphism in the epidermal growth factor gene is associated with birthweight in Sinhalese and white Western Europeans.
MedLine Citation:
PMID:  17392355     Owner:  NLM     Status:  MEDLINE    
Birthweight predicts health later in life and is influenced by inherited factors. We investigated the association of the c.61G > A, and c.2566G > A polymorphisms in the epidermal growth factor (EGF) gene [GenBank NM_001963] with birthweight in three groups of healthy pregnant women, and in women with pregnancies affected by fetal growth restriction (FGR). Subjects comprised 171 Sinhalese women with normal pregnancies (Group A), 64 white Western European women with normal pregnancies (Group B), 101 white Western European women with normal pregnancies and their babies (Group C) and 107 women with pregnancies affected by FGR, their partners and their babies (Group D). Maternal EGF genotypes were associated with birthweight of healthy babies of women in Groups A (P = 0.03), B (P = 0.001) and C (P = 0.01). The association persisted following adjustment for confounding by gestational age, sex, maternal weight, parity and smoking habit. The trend from heaviest to lightest birthweights in all these groups was c.61AA > c.61GA > c.61GG and c.2566GG > c.2566GA > c.2566AA. The EGF haplotype associated with lower birthweight (c.61G, c.2566A) was transmitted at increased frequency from heterozygous parents to babies affected by FGR in Group D (P = 0.02). These findings support the hypothesis that growth factors expressed by the feto-maternal unit affect birthweight, and implicates polymorphism in the EGF gene in the aetiology of birthweight variability.
V H W Dissanayake; C Tower; A Broderick; L J Stocker; H R Seneviratne; R W Jayasekara; N Kalsheker; F Broughton Pipkin; L Morgan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-28
Journal Detail:
Title:  Molecular human reproduction     Volume:  13     ISSN:  1360-9947     ISO Abbreviation:  Mol. Hum. Reprod.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-18     Completed Date:  2007-08-03     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  9513710     Medline TA:  Mol Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  425-9     Citation Subset:  IM    
Human Genetics Unit, Faculty of Medicine, University of Colombo, Sri Lanka.
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MeSH Terms
Birth Weight / genetics*
Case-Control Studies
Epidermal Growth Factor / genetics*
Europe / epidemiology
European Continental Ancestry Group / genetics
Fetal Growth Retardation / genetics
Gene Frequency
Polymorphism, Genetic*
Sri Lanka / epidemiology
Grant Support
//Wellcome Trust
Reg. No./Substance:
62229-50-9/Epidermal Growth Factor

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