| A polymorphism in the serotonin transporter gene moderates cardiovascular reactivity to psychosocial stress. | |
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MedLine Citation:
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PMID: 21364196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine whether a polymorphism (5-HTTLPR: serotonin transporter linked polymorphic region) in the promoter of the serotonin transporter gene (SLC6A4) moderates cardiovascular reactivity to social threat. METHODS: Psychologically healthy young adults delivered a speech and performed mental arithmetic in one of three conditions: a) an evaluative audience condition that gave disapproving and negative nonverbal social signals (n = 59); b) an evaluative audience condition that provided supportive social signals (n = 60); or c) a no audience condition (n = 65). Heart rate (HR) and systolic and diastolic blood pressures (DBP) were measured before, during, and after the stress tasks to assess cardiovascular reactivity and recovery. RESULTS: In the negative audience condition, there was a significant association between the 5-HTTLPR and systolic blood pressure, DBP, and HR reactivity. Individuals with the short/short genotype showed the greatest reactivity. The DBP and HR reactivity of short/short individuals in the negative audience condition was also greater than that of individuals with the short/short genotype in the no audience condition. These associations of the 5-HTLPR with HR reactivity were moderated by gender, being limited to females. With respect to cardiovascular recovery, short/short individuals in the negative audience condition exhibited impaired DBP recovery relative to other genotypes in the same condition, as well as short/short individuals in the no audience condition. CONCLUSIONS: The 5-HTTLPR moderates cardiovascular reactivity to stress in a threatening evaluative social context, which suggests that the serotonin system may be involved in the processes by which stressful, conflict-ridden social environments affect risk for cardiovascular-related health outcomes. |
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Authors:
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Baldwin M Way; Shelley E Taylor |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-03-01 |
Journal Detail:
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Title: Psychosomatic medicine Volume: 73 ISSN: 1534-7796 ISO Abbreviation: Psychosom Med Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-09 Completed Date: 2012-03-15 Revised Date: 2012-09-24 |
Medline Journal Info:
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Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: United States |
Other Details:
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Languages: eng Pagination: 310-7 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095-1563, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Alleles Analysis of Variance Blood Pressure / genetics*, physiology Ethnic Groups European Continental Ancestry Group Female Genotype Heart Rate / genetics*, physiology Humans Male Nonverbal Communication Polymorphism, Genetic / genetics Promoter Regions, Genetic Psychological Tests Serotonin / genetics*, physiology Serotonin Plasma Membrane Transport Proteins / genetics* Sex Characteristics Social Distance* Stress, Psychological / genetics*, physiopathology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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AG030309/AG/NIA NIH HHS; R01 AG030309-01/AG/NIA NIH HHS; R01 AG030309-02/AG/NIA NIH HHS; R01 AG030309-03/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins; 50-67-9/Serotonin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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