Document Detail


A polymorphism in the serotonin transporter gene moderates cardiovascular reactivity to psychosocial stress.
MedLine Citation:
PMID:  21364196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine whether a polymorphism (5-HTTLPR: serotonin transporter linked polymorphic region) in the promoter of the serotonin transporter gene (SLC6A4) moderates cardiovascular reactivity to social threat.
METHODS: Psychologically healthy young adults delivered a speech and performed mental arithmetic in one of three conditions: a) an evaluative audience condition that gave disapproving and negative nonverbal social signals (n = 59); b) an evaluative audience condition that provided supportive social signals (n = 60); or c) a no audience condition (n = 65). Heart rate (HR) and systolic and diastolic blood pressures (DBP) were measured before, during, and after the stress tasks to assess cardiovascular reactivity and recovery.
RESULTS: In the negative audience condition, there was a significant association between the 5-HTTLPR and systolic blood pressure, DBP, and HR reactivity. Individuals with the short/short genotype showed the greatest reactivity. The DBP and HR reactivity of short/short individuals in the negative audience condition was also greater than that of individuals with the short/short genotype in the no audience condition. These associations of the 5-HTLPR with HR reactivity were moderated by gender, being limited to females. With respect to cardiovascular recovery, short/short individuals in the negative audience condition exhibited impaired DBP recovery relative to other genotypes in the same condition, as well as short/short individuals in the no audience condition.
CONCLUSIONS: The 5-HTTLPR moderates cardiovascular reactivity to stress in a threatening evaluative social context, which suggests that the serotonin system may be involved in the processes by which stressful, conflict-ridden social environments affect risk for cardiovascular-related health outcomes.
Authors:
Baldwin M Way; Shelley E Taylor
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-03-01
Journal Detail:
Title:  Psychosomatic medicine     Volume:  73     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-09     Completed Date:  2012-03-15     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  310-7     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095-1563, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alleles
Analysis of Variance
Blood Pressure / genetics*,  physiology
Ethnic Groups
European Continental Ancestry Group
Female
Genotype
Heart Rate / genetics*,  physiology
Humans
Male
Nonverbal Communication
Polymorphism, Genetic / genetics
Promoter Regions, Genetic
Psychological Tests
Serotonin / genetics*,  physiology
Serotonin Plasma Membrane Transport Proteins / genetics*
Sex Characteristics
Social Distance*
Stress, Psychological / genetics*,  physiopathology
Young Adult
Grant Support
ID/Acronym/Agency:
AG030309/AG/NIA NIH HHS; R01 AG030309-01/AG/NIA NIH HHS; R01 AG030309-02/AG/NIA NIH HHS; R01 AG030309-03/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins; 50-67-9/Serotonin
Comments/Corrections

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