Document Detail


Polymorphism in APOB associated with increased low-density lipoprotein levels in both genders in the general population.
MedLine Citation:
PMID:  16030169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Rare mutations in APOB cause hypercholesterolemia. Whether common polymorphisms in APOB have similar effects remains controversial. OBJECTIVE: We tested the hypothesis that the APOB 7673C>T polymorphism (T2488T) is associated with variation in low-density lipoprotein (LDL) levels and with risk of ischemic heart disease (IHD), ischemic cerebrovascular disease (ICVD), and total mortality in the general population. DESIGN: The design was a cohort study with 22-yr follow-up (166,232 person years) and two case-control studies, The Copenhagen City Heart Study. SETTINGS: The study was performed within the Danish general population and at a university hospital. PARTICIPANTS: The study was comprised of 9185 individuals from the general population, 2157 patients with IHD, and 378 patients with ICVD. MAIN OUTCOME MEASURES: The main outcome measures were lipids, lipoproteins, apolipoproteins (apo), IHD, ICVD, and total mortality. RESULTS: Genotype was associated with increases in total cholesterol (women/men), LDL cholesterol, and apoB of 0.20/0.26 mmol/liter (3.3%/4.4%), 0.22/0.28 mmol/liter (5.9%/7.8%), and 5.0/5.6 mg/dl (5.9%/6.7%) in TT vs. CC homozygotes, respectively. These results were consistent over time. Despite this, the 7673C>T polymorphism was not associated with risk of IHD, ICVD, or total mortality prospectively or in case-control studies. CONCLUSION: The APOB 7673C>T polymorphism is associated with moderate increases in total cholesterol, LDL cholesterol, and apoB in both genders in the general population, but not with risk of IHD, ICVD, or total mortality.
Authors:
Marianne Benn; Børge G Nordestgaard; Jan S Jensen; Peer Grande; Henrik Sillesen; Anne Tybjaerg-Hansen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-07-19
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  90     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-06     Completed Date:  2005-11-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5797-803     Citation Subset:  AIM; IM    
Affiliation:
Department of Clinical Biochemistry, KB3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Apolipoproteins B / genetics*
Case-Control Studies
Cholesterol / blood
Cholesterol, LDL / blood
Cohort Studies
Denmark / epidemiology
Female
Gene Frequency
Genotype
Humans
Lipoproteins, LDL / blood*
Lipoproteins, VLDL / blood
Male
Middle Aged
Myocardial Ischemia / epidemiology
Polymorphism, Genetic / physiology*
Population
Prospective Studies
Chemical
Reg. No./Substance:
0/Apolipoproteins B; 0/Cholesterol, LDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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