| Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus in Chinese population. | |
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MedLine Citation:
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PMID: 11189236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the possible association between the Xbal polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus (NIDDM) in Chinese population. METHODS: 216 NIDDM patients and 106 healthy controls were studied. DNA fragment containing Xbal restriction site was amplified by the polymerase chain reaction, digested by the Xbal enzyme and compared by gel electrophoresis with a positive control from Finland. RESULTS: The Xbal polymorphism was found in 18 of 216 Chinese patients (8.3%) and was also found in 10 of 106 controls (9.4%) (P > 0.05). CONCLUSIONS: The results suggest that the Xbal polymorphism of the glycogen synthase gene could not be used as a genetic marker for NIDDM in Chinese population of Henan Han nationality. |
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Authors:
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C Wang; Y Bai; A Ouyang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 111 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 2001-01-12 Completed Date: 2001-03-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 903-5 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, First Affiliated Hospital, Henan Medical University, Zhengzhou 450052, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Alleles Asian Continental Ancestry Group Deoxyribonucleases, Type II Site-Specific / genetics* Diabetes Mellitus, Type 2 / enzymology, genetics* Genetic Markers Glycogen Synthase / genetics* Humans Middle Aged Polymerase Chain Reaction Polymorphism, Genetic* |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; EC 2.4.1.11/Glycogen Synthase; EC 3.1.21.-/endodeoxyribonuclease XBAI; EC 3.1.21.4/Deoxyribonucleases, Type II Site-Specific |
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