Document Detail


Polymorphism of glutathione S-transferase omega gene and risk of cancer.
MedLine Citation:
PMID:  15992993     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polymorphic glutathione S-transferase (GST) genes causing variations in enzyme activity may influence individual susceptibility to cancer. Though polymorphisms have been reported in GSTO1 and GSTO2, their predisposition to cancer risk has not yet been explored. In this case control study, 28 cases of hepatocellular carcinoma, 30 cases of cholangiocarcinoma, 31 cases of colorectal cancer, 30 cases of breast cancer and 98 controls were compared for frequencies of GSTO1 and GSTO2 genotypes. The statistical analysis provided the support for the difference in genotypic distribution for GSTO1*A140D between hepatocellular carcinoma (OR 23.83, CI 95%: 5.07-127), cholangiocarcinoma (OR 8.5, CI 95%: 2.07-37.85), breast cancer (OR 3.71, CI 95%: 1.09-13.02) and control. With regards to GSTO2*N140D polymorphism, there was no difference in genotypic distribution between all the types of cancer and control. The study suggests that GSTO1*A140D polymorphism could play an important role as a risk factor for the development of hepatocellular carcinoma, cholangiocarcinoma and breast cancer.
Authors:
Sujan Babu Marahatta; Phaibul Punyarit; Vajarabhongsa Bhudisawasdi; Anucha Paupairoj; Sopit Wongkham; Songsak Petmitr
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-29
Journal Detail:
Title:  Cancer letters     Volume:  236     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-22     Completed Date:  2006-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  276-81     Citation Subset:  IM    
Affiliation:
Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Bile Duct Neoplasms / genetics*
Bile Ducts, Intrahepatic*
Breast Neoplasms / genetics*
Carcinoma, Hepatocellular / genetics*
Case-Control Studies
Cholangiocarcinoma / genetics*
Female
Gene Frequency
Genotype
Glutathione Transferase / genetics*
Humans
Liver Neoplasms / genetics*
Male
Polymorphism, Genetic*
Risk Factors
Thailand
Chemical
Reg. No./Substance:
EC 2.5.1.18/GSTO1 protein, human; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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