| Polymorphism of detoxification genes and cell resistance to mutagens in patients with Ehlers-Danlos syndrome. | |
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MedLine Citation:
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PMID: 18683505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Study of polymorphism in 3 genes of the glutathione S-transferase family (GSTM1, GSTT1, and GSTP1) in children with Ehlers-Danlos syndrome whose cells were defective in repair of gamma-induced DNA damages revealed accumulation of GSTM1(+) genotypes compared to children of the control group. Generation of reactive oxygen species by neutrophils from patients with this syndrome was higher than in healthy donors. Our results indicate that glutathione S-transferase genes are involved in the resistance to mutagenic agents and demonstrate medical and genetic peculiarities of patients with Ehlers-Danlos syndrome. |
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Authors:
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N S Kuz'mina; E V Shipaeva; A N Semyachkina; I M Vasil'eva; L P Kovalenko; A D Durnev; G D Zasukhina |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 144 ISSN: 0007-4888 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2008-08-07 Completed Date: 2008-12-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 717-21 Citation Subset: IM |
Affiliation:
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N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Cadmium Chloride / pharmacology Child DNA Damage Drug Resistance Ehlers-Danlos Syndrome / blood, genetics* Female Gamma Rays Gene Frequency Genetic Predisposition to Disease / genetics Genotype Glutathione Transferase / genetics Humans Lymphocytes / drug effects, metabolism*, radiation effects Male Mutagens / pharmacology* Polymorphism, Genetic* Reactive Oxygen Species / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Mutagens; 0/Reactive Oxygen Species; 10108-64-2/Cadmium Chloride; EC 2.5.1.-/glutathione S-transferase T1; EC 2.5.1.18/Glutathione Transferase; EC 2.5.1.18/glutathione S-transferase M1 |
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