Document Detail

Polymorphism of the beta3-adrenergic receptor gene and weight gain in pregnant diabetic women.
MedLine Citation:
PMID:  10414939     Owner:  NLM     Status:  MEDLINE    
Inappropriate body weight gain during pregnancy has critical effects on the outcome for both mother and fetus. Therefore, body weight gain is an important issue in the management of pregnancy in women with diabetes. A Trp64Arg substitution in the beta3-AR gene has been reported to be associated with body weight gain and obesity in non-insulin-dependent diabetes mellitus (NIDDM) subjects. The aim of this study was to elucidate the contribution of the beta3-AR gene to body weight gain during pregnancy in subjects with diabetes. We analyzed 199 diabetic patients (NIDDM/IDDM; 131/68) and patient data was obtained from the first delivery of each individual. The mean age at diagnosis of diabetes was 22.9 +/- 7.5 years (mean +/- S.D.) and the mean age at delivery was 29.8 +/- 4.5 years. A polymorphism of the beta3-AR gene was detected by PCR-RFLP using Bst OI, which recognizes a Trp64Arg substitution. The frequency of the Trp64Arg allele was 0.15 in NIDDM and 0.17 in IDDM. Among the NIDDM subjects, excess weight gain during pregnancy, as defined by maximum BMI during pregnancy minus basal BMI before pregnancy exceeding five, was observed in 12.2% of the wild-type patients, 19.2% of heterozygotes and 28.6% of homozygotes. Homozygous subjects with NIDDM tended to show excess weight gain during pregnancy, however, this trend did not reach significance. None of the IDDM homozygotes showed excess weight gain. From our study, this beta3-AR gene polymorphism cannot be excluded as a contributing factor to excess weight gain during pregnancy in NIDDM subjects.
K Yanagisawa; N Iwasaki; M Sanaka; S Minei; M Kanamori; Y Omori; Y Iwamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  44     ISSN:  0168-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-09-08     Completed Date:  1999-09-08     Revised Date:  2004-11-18    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  41-7     Citation Subset:  IM    
Diabetes Center, Tokyo Women's Medical University, Japan.
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MeSH Terms
Amino Acid Substitution
Body Mass Index
Diabetes Mellitus / genetics,  physiopathology
Diabetes Mellitus, Type 1 / genetics,  physiopathology
Diabetes Mellitus, Type 2 / genetics,  physiopathology
Polymorphism, Genetic*
Pregnancy in Diabetics / genetics*,  physiopathology*
Receptors, Adrenergic, beta / genetics*
Receptors, Adrenergic, beta-3
Weight Gain / genetics*
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 0/Receptors, Adrenergic, beta-3; 73-22-3/Tryptophan; 74-79-3/Arginine
Erratum In:
Diabetes Res Clin Pract 2000 May;48(2):153

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