Document Detail

Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease.
MedLine Citation:
PMID:  9428619     Owner:  NLM     Status:  MEDLINE    
The angiotensin-converting enzyme (ACE) is an integral part of two enzymatic cascades, one leading to the generation of angiotensin II and the other to the degradation of bradykinin. The great variety of cardiovascular effects mediated by these vasoactive peptides and the efficacy of ACE inhibitors in the treatment of hypertension and heart failure emphasize the prominent role of ACE in the cardiovascular system. Early in this decade convincing experimental evidence demonstrated the induction of this enzyme in several pathophysiological conditions, including myocardial infarction and left ventricular hypertrophy. In parallel, a deletion/insertion (D/I) polymorphism of the human ACE gene was characterized that is related to 14-50% of the interindividual variance in serum ACE activity. More recently this polymorphism has been implicated in the pathogenesis of a variety of cardiovascular disorders, including myocardial infarction, left ventricular hypertrophy, hypertension, diabetic and IgA nephropathy, carotid artery thickening, and lacunar cerebral stroke. However, the associations between the ACE D/I polymorphism and most of these conditions were found to be inconsistent when additional populations were investigated. This contribution reviews the current evidence on the relationship between the ACE D/I polymorphism and cardiovascular disease.
H Schunkert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of molecular medicine (Berlin, Germany)     Volume:  75     ISSN:  0946-2716     ISO Abbreviation:  J. Mol. Med.     Publication Date:    1997 Nov-Dec
Date Detail:
Created Date:  1998-02-09     Completed Date:  1998-02-09     Revised Date:  2011-07-08    
Medline Journal Info:
Nlm Unique ID:  9504370     Medline TA:  J Mol Med (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  867-75     Citation Subset:  IM    
Klinik und Poliklinik für Innere Medizin II, Universität Regensburg, Germany.
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MeSH Terms
Cardiovascular Diseases / genetics*
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic*
Reg. No./Substance:

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