Document Detail


Polymorphism of the angiotensin-converting enzyme (ACE) and angiotesinogen (AGT) genes and their associations with blood pressure and carotid artery intima media thickness among healthy Finnish young adults--the Cardiovascular Risk in Young Finns Study.
MedLine Citation:
PMID:  16387306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The roles of angiotensin converting enzyme (ACE) insertion-deletion (I/D) and angiotensinogen (AGT) m235t polymorphisms in cardiovascular diseases have been investigated extensively during the past decade but results have been inconsistent. A sex-specific association between the ACE I/D polymorphism and systolic blood pressure (BP) was seen among Finnish children and adolescents previously. We investigated if these polymorphisms associate with the BP and carotid artery intima media thickness (IMT) in the same cohort during their adulthood. IMT data were available for 224 ACE I/D genotyped individuals and 202 AGT m235t genotyped individuals. Systolic and diastolic blood pressure values did not differ between ACE and AGT genotypes. Age and BMI adjusted mean IMT was 0.02 (95% CI: -0.05 to 0.02, p=0.33) and 0.03 mm (95% CI: -0.07 to 0.001, p=0.06) lower among the ID and DD genotype groups, respectively, compared to the II genotype group. MT and TT genotype groups had 0.02 mm (95% CI: -0.01 to 0.05, p=0.17) higher and 0.01 mm (95% CI: -0.04 to 0.02, p=0.59) lower mean IMT, respectively, compared to the MM genotype group. We conclude that ACE I/D and AGT m235t polymorphisms are not associated with carotid IMT in healthy young Finnish adults.
Authors:
Md Shaheenul Islam; Terho Lehtimäki; Markus Juonala; Mika Kähönen; Nina Hutri-Kähönen; Katariina Kainulainen; Helena Miettinen; Leena Taittonen; Kimmo Kontula; Jorma S A Viikari; Olli T Raitakari
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-04
Journal Detail:
Title:  Atherosclerosis     Volume:  188     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-04     Completed Date:  2007-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  316-22     Citation Subset:  IM    
Affiliation:
Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and The University of Tampere, Medical School, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Angiotensinogen / genetics*
Apolipoproteins / analysis
Blood Pressure / genetics*
Body Mass Index
C-Reactive Protein / analysis
Carotid Arteries / cytology*
Female
Finland
Humans
Lipids / blood
Male
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic*
Tunica Intima / cytology*
Chemical
Reg. No./Substance:
0/Apolipoproteins; 0/Lipids; 11002-13-4/Angiotensinogen; 9007-41-4/C-Reactive Protein; EC 3.4.15.1/ACE protein, human; EC 3.4.15.1/Peptidyl-Dipeptidase A

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