Document Detail

Polymorphism of the PRNP gene in the main breeds of indigenous Chinese goats.
MedLine Citation:
PMID:  18369524     Owner:  NLM     Status:  MEDLINE    
The polymorphism of the PRNP gene plays a key role in susceptibility to prion disease. Scrapie is a neurodegenerative disease affecting sheep and goats and belongs to the group of prion diseases. We isolated DNA from 333 goat samples representing the main local goat breeds in six provinces in China to identify PRNP polymorphisms and to determine whether these breeds were at risk for developing scrapie. Two novel amino acid polymorphisms (R211G and T219I) and a novel silent mutation at codon 125 as well as nine previously reported polymorphisms were observed. Twenty-eight alleles and forty-nine different genotypes were obtained. The codon 142M associated with resistance of goat scrapie was not found in this study. The codon 143R was relatively rare. The codon 222K, a potentially useful candidate site for selecting for scrapie resistance, was also rare in indigenous Chinese goats. These results could provide some useful data for assessing the risk of scrapie in Chinese indigenous goats.
R Y Zhou; X L Li; L H Li; H Y Wang; J G Lü
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-28
Journal Detail:
Title:  Archives of virology     Volume:  153     ISSN:  0304-8608     ISO Abbreviation:  Arch. Virol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506870     Medline TA:  Arch Virol     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  979-82     Citation Subset:  IM    
College of Animal Science and Technology, Agricultural University of Hebei, No. 289 Lingyusi Street, 071001 Baoding, Hebei, People's Republic of China.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Codon / genetics
DNA Primers / genetics
Goat Diseases / genetics
Goats / genetics*
Polymorphism, Genetic*
Prions / genetics*
Scrapie / genetics
Species Specificity
Reg. No./Substance:
0/Codon; 0/DNA Primers; 0/Prions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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