Document Detail


Polymorphism of IL-1alpha(-889) Gene and Its Association with Aggressive Periodontitis.
MedLine Citation:
PMID:  19671938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adult periodontitis is a complex multifactorial disease whose etiology is not well defined. The pro-inflammatory and bone resorption properties of Interleukine-1alpha (IL-1alpha) strongly suggest a role for this cytokine in the pathogenesis of periodontal disease. Eighty Iranian adult patients with periodontitis and 80 Iranian controls were investigated in this study.In this study we report that the frequency of IL-1alpha genotypes including allele 2 of the IL-1alpha(-889) restriction fragment length bi-allele polymorphism were significantly increased in patients with advanced aggressive adult periodontitis compared to those with early and moderate disease. Furthermore, allele 2 was associated with increased production of IL-1alpha by activated peripheral blood polymorphonuclear cells of patients with advanced disease, although this increase failed to reach statistical significance. Finally, the data obtained revealed significant linkage disequilibrium between allele 2 of the IL-1alpha (-889) polymorphism and allele 2 of the bi-allelic IL-1beta (+3953) polymorphism in both patients and orally normal controls. These findings provide new insight into the possible rate of IL-1alpha and beta genes polymorphism in the susceptibility to adult periodontitis.
Authors:
Zahra Kiani; Jalil Tavakkol-Afshari; Hamed Hojjat; Hamid Reza Arab; Mehrdad Radvar; Mehrdad Sadeghizadeh; Ahmad Reza Ebadian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Iranian journal of allergy, asthma, and immunology     Volume:  8     ISSN:  1735-1502     ISO Abbreviation:  Iran J Allergy Asthma Immunol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-08-12     Completed Date:  2009-11-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101146178     Medline TA:  Iran J Allergy Asthma Immunol     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
Affiliation:
Department of Immunology, Chabahar International University of Medical Sciences, Chabahar, Iran. zkiani604@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aggressive Periodontitis / genetics*
Alleles
Female
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Humans
Interleukin-1alpha / genetics*
Interleukin-1beta / genetics*
Linkage Disequilibrium
Male
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length / genetics
Chemical
Reg. No./Substance:
0/Interleukin-1alpha; 0/Interleukin-1beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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