Document Detail

Polymorphism of CYP11B2 determines salt sensitivity in Japanese.
MedLine Citation:
PMID:  17296872     Owner:  NLM     Status:  MEDLINE    
Aldosterone plays essential roles in body fluid and electrolyte homeostasis and blood pressure. However, the association between polymorphisms in the CYP11B2 gene and hypertension is controversial. We resequenced CYP11B1 and CYP11B2 and identified 35 polymorphisms in this region. We performed association studies between the plasma aldosterone concentration and 13 polymorphisms in this region in 1443 subjects. The subjects were all obtained from the Suita Cohort Study. Multiple regression analysis indicated that aldosterone levels were determined by renin activity, age, total cholesterol, and hematocrit. Residuals of the aldosterone levels after adjusting for these confounding factors were nominally associated with the T(-344)C (P=0.0026), C(595)T (P=0.0180), -(4837)C (P=0.0310), and G(4936)A (P=0.0498) polymorphisms. Only the T(-344)C polymorphism was significantly associated with the aldosterone level after a correction for multiple testing (Bonferroni). A significant interaction was observed between the T(-344)C polymorphism and renin activity in determining aldosterone levels. Moreover, a significant interaction was observed in 2063 subjects between urinary sodium excretion, which reflects sodium intake, and the T(-344)C polymorphism in determining systolic blood pressure. Only subjects with the TT genotype showed a positive correlation between urinary sodium excretion and systolic blood pressure. In vitro experiments confirmed the functional significance of this T(-344)C polymorphism in terms of angiotensin II reactivity. Thus, the T(-344)C polymorphism in CYP11B2 appears to affect salt sensitivity in Japanese and to have clinical significance.
Naoharu Iwai; Kazuaki Kajimoto; Hitonobu Tomoike; Naoyuki Takashima
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-12
Journal Detail:
Title:  Hypertension     Volume:  49     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-22     Completed Date:  2007-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  825-31     Citation Subset:  IM    
Department of Epidemiology, National Cardiovascular Center, Suita, Osaka, Japan.
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MeSH Terms
Aldosterone / blood
Aldosterone Synthase / genetics*
Asian Continental Ancestry Group / genetics*
Blood Pressure / genetics
Cohort Studies
Hypertension / blood,  chemically induced*,  genetics*,  physiopathology
Middle Aged
Natriuresis / genetics
Polymorphism, Genetic*
Renin / blood
Sequence Analysis
Sodium Chloride / adverse effects*
Steroid 11-beta-Hydroxylase / genetics
Reg. No./Substance:
52-39-1/Aldosterone; 52-90-4/Cysteine; 72-19-5/Threonine; 7647-14-5/Sodium Chloride; EC Synthase; EC 11-beta-Hydroxylase; EC

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