Document Detail


Polymorphic transformation of anhydrous caffeine upon grinding and hydrostatic pressurizing analyzed by low-frequency raman spectroscopy.
MedLine Citation:
PMID:  23108633     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Low-frequency Raman investigations were carried out upon pressurizing and grinding both crystalline forms of anhydrous caffeine at room temperature. These investigations have led to the detection of metastable states under stress. Upon moderated hydrostatic compression, only form I transform into a metastable state characterized by a Raman band-shape resembling that of form II. Above 2 GPa, both pressurized forms convert into an identical disordered state, suggesting a pressure-induced amorphization. In contrast to hydrostatic compression, grinding induces transformation of each phase into the other, leading to an intermediate state only stabilized under long enough grinding. The origin of these metastable states induced by stress was related to the disordered nature of both crystalline forms of caffeine and the stability conditions at room temperature of form I. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.
Authors:
Alain Hédoux; Yannick Guinet; Laurent Paccou; Florence Danède; Patrick Derollez
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-25
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  -     ISSN:  1520-6017     ISO Abbreviation:  J Pharm Sci     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Univ Lille Nord de France, France USTL, UMET UMR 8207, F-59650 Villeneuve d';Ascq, France. alain.hedoux@univ-lille1.fr.
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