Document Detail


Polymorphic exocellular protease expression in clinical isolates of Trichophyton tonsurans.
MedLine Citation:
PMID:  11469758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tinea capitis continues to be an overwhelmingly prevalent disease in children. Despite the fact that it was recognized over a century ago, the factors that dictate the divergent clinical presentations seen with tinea capitis (e.g., carrier state, chronic non-inflammatory infection, acute severely-inflammatory infection) remain unknown. Given the pathogenic role of exocellular proteases in dermatophyte infections and their potential immunogenic role, this investigation was designed to characterize strain-specific variability in fungal protease expression and activity in Trichophyton tonsurans isolates identified from children with tinea capitis.
Authors:
S M Abdel-Rahman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mycopathologia     Volume:  150     ISSN:  0301-486X     ISO Abbreviation:  Mycopathologia     Publication Date:  2001  
Date Detail:
Created Date:  2001-07-25     Completed Date:  2002-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505689     Medline TA:  Mycopathologia     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  117-20     Citation Subset:  IM    
Affiliation:
University of Missouri-Kansas City School of Pharmacy, USA. srahman@cmh.edu
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MeSH Terms
Descriptor/Qualifier:
Child
Collagenases / biosynthesis
Endopeptidases / biosynthesis*,  classification
Humans
Pancreatic Elastase / biosynthesis
Peptide Hydrolases / biosynthesis
Tinea Capitis / microbiology*
Trichophyton / enzymology*,  isolation & purification
Chemical
Reg. No./Substance:
EC 3.4.-/Endopeptidases; EC 3.4.-/Peptide Hydrolases; EC 3.4.-/keratinase; EC 3.4.21.36/Pancreatic Elastase; EC 3.4.24.-/Collagenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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