Document Detail

Polymorphic acetylation and aminopyrine demethylation in Gilbert's syndrome.
MedLine Citation:
PMID:  100326     Owner:  NLM     Status:  MEDLINE    
Polymorphic acetylation was investigated in twenty-seven patients with Gilbert's syndrome using the sulphadimidine test. Whereas the finding of 51% slow acetylators in seventy-eight control persons agreed well with the expected frequency in a continental European population, the prevalence of slow acetylators in Gilbert's syndrome was increased to 78% (P less than 0.03, Woolf's G-test). After oral administration of 14C-aminopyrine there was no significant difference between seventeen patients with Gilbert's syndrome and twenty-seven normal controls in total plasma clearance of aminopyrine (280 +/- SD 100 and 270 +/- 60 ml/min) and in the disappearance curve of 14CO2 in breath (0.23 +/- 0.04 and 0.22 +/- 0.03 h-1, respectively). Thus, whereas aminopyrine metabolism appears unaffected in the examined patients, the data documents a new association between slow acetylator status and Gilbert's syndrome.
R Platzer; A Küpfer; J Bircher; R Preisig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  8     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-12-27     Completed Date:  1978-12-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  219-23     Citation Subset:  IM    
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MeSH Terms
Aminopyrine / metabolism*
Gilbert Disease / genetics,  metabolism*
Hyperbilirubinemia, Hereditary / metabolism*
Middle Aged
Sulfamethazine / metabolism*
Reg. No./Substance:
57-68-1/Sulfamethazine; 58-15-1/Aminopyrine

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