Document Detail

Polymerized-type I collagen downregulates inflammation and improves clinical outcomes in patients with symptomatic knee osteoarthritis following arthroscopic lavage: a randomized, double-blind, and placebo-controlled clinical trial.
MedLine Citation:
PMID:  22545014     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Polymerized-type I collagen (polymerized collagen) is a downmodulator of inflammation and cartilage regenerator biodrug.
AIM: To evaluate the effect of intraarticular injections of polymerized collagen after arthroscopic lavage on inflammation and clinical improvement in patients with knee osteoarthritis (OA).
METHODS: Patients (n = 19) were treated with 6 intraarticular injections of 2 mL of polymerized collagen (n = 10) or 2 mL of placebo (n = 9) during 3 months. Followup was 3 months. The primary endpoints included Lequesne index, pain on a visual analogue scale (VAS), WOMAC, analgesic usage, the number of Tregs and proinflammatory/anti-inflammatory cytokine-expressing peripheral cells. Secondary outcomes were Likert score and drug evaluation. Clinical and immunological improvement was determined if the decrease in pain exceeds 20 mm on a VAS, 20% of clinical outcomes, and inflammatory parameters from baseline. Urinary levels of C-terminal crosslinking telopeptide of collagen type II (CTXII) and erythrocyte sedimentation rate (ESR) were determined.
RESULTS: Polymerized collagen was safe and well tolerated. Patients had a statistically significant improvement (P < 0.05) from baseline versus polymerized collagen and versus placebo at 6 months on Lequesne index, VAS, ESR, Tregs IL-1β, and IL-10 peripheral-expressing cells. Urinary levels of CTXII were decreased 44% in polymerized collagen versus placebo. No differences were found on incidence of adverse events between groups.
CONCLUSION: Polymerized collagen is safe and effective on downregulation of inflammation in patients with knee OA.
Janette Furuzawa-Carballeda; Guadalupe Lima; Luis Llorente; Carlos Nuñez-Álvarez; Blanca H Ruiz-Ordaz; Santiago Echevarría-Zuno; Virgilio Hernández-Cuevas
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-04-01
Journal Detail:
Title:  TheScientificWorldJournal     Volume:  2012     ISSN:  1537-744X     ISO Abbreviation:  ScientificWorldJournal     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-30     Completed Date:  2012-07-13     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  101131163     Medline TA:  ScientificWorldJournal     Country:  England    
Other Details:
Languages:  eng     Pagination:  342854     Citation Subset:  IM    
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Col Sección XVI, 14000 Mexico City, DF, Mexico.
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MeSH Terms
Collagen Type I / therapeutic use*
Combined Modality Therapy
Double-Blind Method
Flow Cytometry
Inflammation / drug therapy*
Leukocytes, Mononuclear / cytology
Middle Aged
Osteoarthritis, Knee / drug therapy*,  surgery
Therapeutic Irrigation*
Treatment Outcome
Reg. No./Substance:
0/Collagen Type I; 0/Placebos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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