Document Detail


Polymerization of polyfunctional macromolecules: synthesis of a new class of high molecular weight poly(amino acid)s by oxidative coupling of phenol-containing precursor polymers.
MedLine Citation:
PMID:  15132690     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidative coupling of phenol-containing precursor poly(amino acid)s, poly(alpha-glutamine), poly(alpha/beta-asparagine), and poly(gamma-glutamine) derivatives, has been examined to produce a new class of soluble poly(amino acid)s. Under appropriate reaction conditions, the Fe-salen and HRP catalysts efficiently induced the oxidative coupling without formation of insoluble gels, yielding the soluble polymers of high molecular weight. The oxidative coupling behaviors were greatly influenced by the structure and phenol content of the precursor polymer. The selection of the substrate concentration and catalyst amount was crucial for the production of soluble polymers of high molecular weight.
Authors:
Tokuma Fukuoka; Hiroshi Uyama; Shiro Kobayashi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomacromolecules     Volume:  5     ISSN:  1525-7797     ISO Abbreviation:  Biomacromolecules     Publication Date:    2004 May-Jun
Date Detail:
Created Date:  2004-05-10     Completed Date:  2005-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  United States    
Other Details:
Languages:  eng     Pagination:  977-83     Citation Subset:  IM    
Affiliation:
Department of Materials Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemical synthesis*,  chemistry
Biopolymers / chemistry*
Molecular Weight
Nuclear Magnetic Resonance, Biomolecular
Oxidation-Reduction
Phenols / chemistry*
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Biopolymers; 0/Phenols

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