Document Detail

Polymeric nanoparticles composed of fatty acids and polyvinylalcohol for topical application of sunscreens.
MedLine Citation:
PMID:  15025868     Owner:  NLM     Status:  MEDLINE    
Benzophenone-3 (BZP) or oxybenzone is widely used in many cosmetic formulations, such as sunscreen lotions or emulsions, shampoos and hair sprays. The nature of the vehicle used can enhance or block the percutaneous absorption of UV filter. In this work, we hydrophobically modified polyvinylalcohol 10 000 (PVA) with fatty acids (FAs) to obtain PVA-FA derivatives for the preparation of lipophilic polymeric nanoparticles able to prevent BZP movement towards the skin. Synthesized PVA-FA derivatives were confirmed by H1 NMR. Nanoparticles loaded with BZP were prepared using a solvent extraction method. The particle size was monitored by means of dynamic light scattering measurements. In-vitro skin permeation studies were performed.
B Luppi; T Cerchiara; F Bigucci; R Basile; V Zecchi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  56     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-17     Completed Date:  2004-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  407-11     Citation Subset:  IM    
Department of Pharmaceutical Sciences, Bologna University, Via San Donato 19/2, 40127 Bologna, Italy.
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MeSH Terms
Administration, Topical*
Benzophenones / administration & dosage,  chemistry,  pharmacokinetics
Drug Delivery Systems
Fatty Acids / chemistry*
Hexoses / chemistry
Nanotechnology / methods*
Particle Size
Permeability / drug effects
Polymers / chemical synthesis*,  pharmacokinetics
Polysorbates / chemistry
Polyvinyl Alcohol / chemistry*
Skin / drug effects,  metabolism
Skin Absorption / drug effects
Sunscreening Agents / administration & dosage*,  pharmacokinetics
Reg. No./Substance:
0/Benzophenones; 0/Fatty Acids; 0/Hexoses; 0/Polymers; 0/Polysorbates; 0/Sunscreening Agents; 131-57-7/oxybenzone; 1338-43-8/sorbitan monooleate; 9002-89-5/Polyvinyl Alcohol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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