| Polymeric nanoparticles composed of fatty acids and polyvinylalcohol for topical application of sunscreens. | |
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MedLine Citation:
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PMID: 15025868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Benzophenone-3 (BZP) or oxybenzone is widely used in many cosmetic formulations, such as sunscreen lotions or emulsions, shampoos and hair sprays. The nature of the vehicle used can enhance or block the percutaneous absorption of UV filter. In this work, we hydrophobically modified polyvinylalcohol 10 000 (PVA) with fatty acids (FAs) to obtain PVA-FA derivatives for the preparation of lipophilic polymeric nanoparticles able to prevent BZP movement towards the skin. Synthesized PVA-FA derivatives were confirmed by H1 NMR. Nanoparticles loaded with BZP were prepared using a solvent extraction method. The particle size was monitored by means of dynamic light scattering measurements. In-vitro skin permeation studies were performed. |
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Authors:
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B Luppi; T Cerchiara; F Bigucci; R Basile; V Zecchi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 56 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-17 Completed Date: 2004-07-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 407-11 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, Bologna University, Via San Donato 19/2, 40127 Bologna, Italy. bluppi@biocfarm.unibo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical* Animals Benzophenones / administration & dosage, chemistry, pharmacokinetics Drug Delivery Systems Fatty Acids / chemistry* Hexoses / chemistry Methods Nanotechnology / methods* Particle Size Permeability / drug effects Polymers / chemical synthesis*, pharmacokinetics Polysorbates / chemistry Polyvinyl Alcohol / chemistry* Skin / drug effects, metabolism Skin Absorption / drug effects Sunscreening Agents / administration & dosage*, pharmacokinetics Swine |
| Chemical | |
Reg. No./Substance:
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0/Benzophenones; 0/Fatty Acids; 0/Hexoses; 0/Polymers; 0/Polysorbates; 0/Sunscreening Agents; 131-57-7/oxybenzone; 1338-43-8/sorbitan monooleate; 9002-89-5/Polyvinyl Alcohol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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