| Polymeric micelles with a pH-responsive structure as intracellular drug carriers. | |
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MedLine Citation:
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PMID: 16182401 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polymeric micelles based on poly(L-lactide)-b-poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PLLA-PEOz-PLLA) ABA triblock copolymers were designed as intracellular drug carriers. The PLLA-PEOz-PLLA micelles adopt a "flower-like" arrangement with A-blocks at the core and a B-block on the shell under neutral condition. The deformation of the core-shell structure is then promoted by the aggregation of PEOzs due to the formation of inter- and intra-hydrogen bonding between protonated nitrogen and carbonyl groups. The experiments on in vitro release have confirmed that the release of doxorubicin (DOX) from micelles was successfully inhibited at pH 7.4. In contrast, an accelerated release of DOX from micelles was observed at acidic conditions. The results of growth inhibition assay indicated that the cell-killing rate of DOX-loaded micelles gradually approached that of free DOX as increasing the concentration and the incubation time. The overlay of fluorescent images on CLSM observation clearly demonstrated the colocalization of DOX with acidic compartments, suggesting that the drug release was successfully triggered in the acidic organelles by means of micelle deformation. |
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Authors:
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Chau-Hui Wang; Chun-Hung Wang; Ging-Ho Hsiue |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-22 |
Journal Detail:
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Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 108 ISSN: 0168-3659 ISO Abbreviation: J Control Release Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-24 Completed Date: 2006-01-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
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Languages: eng Pagination: 140-9 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering, National Tsing Hua University, Hsinchu, 300 Taiwan, ROC. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibiotics, Antineoplastic
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chemistry,
pharmacology Cell Survival / drug effects Doxorubicin / chemistry, pharmacology Drug Carriers / chemistry* Hela Cells Humans Hydrogen-Ion Concentration Kinetics Micelles Oxazoles / chemistry Polyesters / chemistry Polymers / chemistry* Solubility |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Drug Carriers; 0/Micelles; 0/Oxazoles; 0/Polyesters; 0/Polymers; 23214-92-8/Doxorubicin; 25805-17-8/polyethyloxazoline; 26969-66-4/poly(lactide) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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