Document Detail


Polymeric cryoprotectants in the preservation of biological ultrastructure. II. Physiological effects.
MedLine Citation:
PMID:  73592     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A study has been made of the physiological effects of three non-penetrating polymeric cryoprotective agents on sixteen different plant and animal cells and tissues. The cryoprotectants, when used at concentrations at which they are effective in preventing ice-crystal formation, generally have a lower toxicity to cells and tissue than similar concentrations of glycerol. The relatively low toxicity of these substances suggests that they would be more suitable as cryoprotectants for morphological and analytical studies than the commonly used low molecular weight compounds.
Authors:
P Echlin; H B Skaer; B O Gardiner; F Franks; M H Asquith
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of microscopy     Volume:  110     ISSN:  0022-2720     ISO Abbreviation:  J Microsc     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1978-02-23     Completed Date:  1978-02-23     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0204522     Medline TA:  J Microsc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  239-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Survival / drug effects*
Cryoprotective Agents / pharmacology*
Dextrans / pharmacology
Freezing
Hetastarch / pharmacology
Methods
Microscopy, Electron*
Polymers / pharmacology*
Povidone / pharmacology
Preservation, Biological*
Spectrometry, X-Ray Emission
Chemical
Reg. No./Substance:
0/Cryoprotective Agents; 0/Polymers; 9003-39-8/Povidone; 9004-54-0/Dextrans; 9005-27-0/Hetastarch

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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