| Polymeric chitosan-based vesicles for drug delivery. | |
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MedLine Citation:
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PMID: 9643437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A simple carbohydrate polymer glycol chitosan (degree of polymerization 800 approx.) has been investigated for its ability to form polymeric vesicle drug carriers. The attachment of hydrophobic groups to glycol chitosan should yield an amphiphilic polymer capable of self-assembly into vesicles. Chitosan is used because the membrane-penetration enhancement of chitosan polymers offers the possibility of fabricating a drug delivery system suitable for the oral and intranasal administration of gut-labile molecules. Glycol chitosan modified by attachment of a strategic number of fatty acid pendant groups (11-16 mol%) assembles into unilamellar polymeric vesicles in the presence of cholesterol. These polymeric vesicles are found to be biocompatible and haemocompatible and capable of entrapping water-soluble drugs. By use of an ammonium sulphate gradient bleomycin (MW 1400), for example, can be efficiently loaded on to these polymeric vesicles to yield a bleomycin-to-polymer ratio of 0.5 units mg(-1). Previously polymers were thought to assemble into vesicles only if the polymer backbone was separated from the membrane-forming amphiphile by a hydrophilic side-arm spacer. The hydrophilic spacer was thought to be necessary to decouple the random motion of the polymer backbone from the ordered amphiphiles that make up the vesicle membrane. However, stable polymeric vesicles for use in drug delivery have been prepared from a modified carbohydrate polymer, palmitoyl glycol chitosan, without this specific architecture. These polymeric vesicles efficiently entrap water-soluble drugs. |
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Authors:
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I F Uchegbu; A G Schätzlein; L Tetley; A I Gray; J Sludden; S Siddique; E Mosha |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 50 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-09-21 Completed Date: 1998-09-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 453-8 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biocompatible Materials
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chemistry* Biopolymers / chemistry Chitin / analogs & derivatives*, chemical synthesis, chemistry Chitosan Drug Delivery Systems* Spectroscopy, Fourier Transform Infrared |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Biopolymers; 0/palmitoyl glycol chitosan; 1398-61-4/Chitin; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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