| Polymer gel in rat skull to assess the accuracy of a new rat stereotactic device for use with the Gamma Knife. | |
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MedLine Citation:
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PMID: 19377849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Accurate targeting is crucial for the irradiation of a small-volume animal brain. We propose an original method, based on a polymer gel, to determine the accuracy and reproducibility of irradiation using a new stereotactic frame. METHODS: An in-house designed rat stereotactic frame, compatible with the Gamma Knife, was constructed. The rat brain was then removed through a small burr hole and the intracranial cavity was washed and filled with a polymer gel. This "gel brain" was irradiated by Gamma Knife and the irradiated volumes and coordinates were measured after the irradiation. RESULTS: The position of the polymerized areas revealed that the stereotactic frame was able to accurately reproduce the same position of irradiation in each animal. The small standard deviation demonstrated the high reproducibility. CONCLUSION: The polymer gel confirmed the ability of the rat stereotactic frame to accurately and reproducibly position a small animal for precise radiosurgery procedures. |
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Authors:
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Gabriel Charest; David Mathieu; Martin Lepage; David Fortin; Benoit Paquette; Léon Sanche |
Publication Detail:
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Type: Journal Article Date: 2009-04-18 |
Journal Detail:
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Title: Acta neurochirurgica Volume: 151 ISSN: 0942-0940 ISO Abbreviation: Acta Neurochir (Wien) Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-09 Completed Date: 2009-09-09 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0151000 Medline TA: Acta Neurochir (Wien) Country: Austria |
Other Details:
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Languages: eng Pagination: 677-83; discussion 683-4 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H5H3, Canada. Gabriel.Charest@USherbrooke.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Neoplasms / surgery* Brain Tissue Transplantation / methods Cell Line, Tumor / transplantation Disease Models, Animal Gels / diagnostic use*, radiation effects Glioma / surgery* Preoperative Care / instrumentation, methods Radiosurgery / instrumentation, methods* Rats Rats, Inbred F344 Reproducibility of Results Skull / anatomy & histology, surgery* Stereotaxic Techniques / instrumentation* Surgical Instruments / trends |
| Chemical | |
Reg. No./Substance:
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0/Gels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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