| Polymer-free Paclitaxel-coated Zilver PTX Stents-Evaluation of Pharmacokinetics and Comparative Safety in Porcine Arteries. | |
| | |
MedLine Citation:
|
PMID: 21419649 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate the pharmacokinetics and safety of the Zilver PTX Drug-Eluting Stent (Cook Medical, Bloomington, Indiana) in a normal porcine artery model. MATERIALS AND METHODS: Pharmacokinetic analyses were performed using 18 pigs, each implanted with four paclitaxel-coated stents. Paclitaxel remaining on the stents, delivered locally (to artery wall), regionally (to adjacent and downstream muscle), and systemically (to plasma), was determined at various times through 56 days. For safety evaluation, local, regional, and systemic responses were grossly and histologically assessed at 1 month, 3 months, and 6 months in 21 additional pigs and compared with the responses to bare metal stents in 21 separate pigs. RESULTS: Stents delivered approximately 95% of the total paclitaxel within 24 hours after deployment. Nonetheless, there were sustained paclitaxel levels in the artery wall through 56 days, maintained at approximately 20% of the peak level through 14 days. Very little paclitaxel was distributed regionally or systemically, becoming undetectable in plasma at 10 hours. Complete necropsy, hematology, and serum chemistry revealed no adverse effects associated with the paclitaxel-coated stents. Within 3 months, vessels with both paclitaxel-coated and bare metal stents showed comparable, complete healing. CONCLUSIONS: The Zilver PTX stent appears to be safe, achieves sustained paclitaxel levels in the artery wall, and shows complete vessel healing comparable to bare metal stents within 3 months. |
| | |
Authors:
|
Michael D Dake; William G Van Alstine; Qing Zhou; Anthony O Ragheb |
Related Documents
:
|
11592509 - Preliminary pediatric transesophageal echocardiography experiences. 6154329 - Double-chambered right ventricle: surgical experience and anatomical considerations. 9692489 - Modified biatrial approach for the extensive resection of left atrial myxomas. 19089969 - Stenting of a stenosed major aortopulmonary collateral artery in a baby with pulmonary ... 11747159 - A late complication with the cardioseal asd occluder device and need for surgical revis... 3826749 - Contrast echocardiography in the evaluation of interatrial septal defect. 3159939 - Management of congenital stenosis of a branch pulmonary artery with balloon dilation an... 23393639 - A rare coronary artery anomaly: double left anterior descending artery. 15222649 - Dvt and pulmonary embolism: part ii. treatment and prevention. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-16 |
Journal Detail:
|
Title: Journal of vascular and interventional radiology : JVIR Volume: - ISSN: 1535-7732 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 SIR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, California. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Temporal stability of dysmorphic fusiform aneurysms of the intracranial internal carotid artery.
Next Document: Long-term Tesio Catheter Access for Hemodialysis Can Deliver High Dialysis Adequacy with Low Complic...