| Polymer-based nanoparticles for the delivery of nucleoside analogues. | |
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MedLine Citation:
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PMID: 17048470 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nucleoside analogues, together with nucleobases and nucleotide analogues, are commonly used in the treatment of cancer and viral infections. In both cases, they act as antimetabolite agents and interfere with the synthesis of cellular or viral nucleic acids. However, the need of high doses due to the rapid elimination of these compounds, to their poor activation, and/or to their non-specific distribution, often leads to side effects and resistances. The present paper aims to review the different types of polymer nanoparticles which have been designed as drug delivery devices to address these issues. Thus, poly(alkylcyanoacrylate) nanoparticles have been demonstrated as potential carriers for antiviral nucleoside analogues, especially for anti-HIV agents, regarding both intravenous and oral routes. Nanoparticles based on polyesters such as poly(lactic acid) and poly(lactide-co-glycolide) have been used as nanocarriers for nucleosides analogues too, and especially for their ocular delivery. Albumin has shown interesting properties in the design of nanoparticles for the same application, but also for the oral administration of anticancer analogues. Finally, new hydrophilic nanoparticles consisting of cross-linked polymer network ('Nanogels') open the perspective to deliver nucleoside analogues within their active triphosphate form. |
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Authors:
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Hervé Hillaireau; Trung Le Doan; Patrick Couvreur |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of nanoscience and nanotechnology Volume: 6 ISSN: 1533-4880 ISO Abbreviation: J Nanosci Nanotechnol Publication Date: 2006 Sep-Oct |
Date Detail:
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Created Date: 2006-10-19 Completed Date: 2006-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101088195 Medline TA: J Nanosci Nanotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 2608-17 Citation Subset: IM |
Affiliation:
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University of Paris XI, Faculty of Pharmacy, UMR CNRS 8612, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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administration & dosage,
chemistry Antiviral Agents / administration & dosage, chemistry Coated Materials, Biocompatible / chemistry* Crystallization / methods* Drug Carriers / chemistry* Nanostructures / chemistry*, ultrastructure Nucleosides / administration & dosage*, chemistry* Particle Size Polymers / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Antiviral Agents; 0/Coated Materials, Biocompatible; 0/Drug Carriers; 0/Nucleosides; 0/Polymers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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