Document Detail

Polylactide conjugates of camptothecin with different drug release abilities.
MedLine Citation:
PMID:  25429566     Owner:  NLM     Status:  In-Data-Review    
Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (Pm = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vitro under different conditions, is possible in both cases and notably, strongly dependent on PLA microstructure. It shows that release properties of drug-PLA conjugates can be tailored by controlled design of the PLA microstructure, and allow in the case of CMPT-PLA conjugates for the development of highly controlled biodegradable CMPT systems-important delivery systems for anti-cancer agents.
Ewa Oledzka; Paweł Horeglad; Zuzanna Gruszczyńska; Andrzej Plichta; Grzegorz Nałęcz-Jawecki; Marcin Sobczak
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Publication Detail:
Type:  Journal Article     Date:  2014-11-25
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  19     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  19460-70     Citation Subset:  IM    
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