Document Detail

Polylactide (LTS) causes less inflammation response than polydioxanone (PDS): a meniscus repair model in sheep.
MedLine Citation:
PMID:  16896739     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Incidence of meniscus injury has increased in today's active society. Arthroscopical refixation yields better results than partial meniscectomy. The best healing rates are achieved by sutures. As non-degradable sutures are permanent foreign bodies, slow absorbable materials are needed. A slow degradable suture with high concentration of polylactide acid, the so-called "long-term suture" (LTS, Panacryl), has been suggested to produce a higher inflammatory response than conventional polymer sutures [Vicryl, Dexon or polydioxanone (PDS)]. The aim of the study was to assess LTS for meniscus repair after a traumatic lesion and to evaluate immunological response, biodegradation and healing.
METHODS: In 24 randomised sheep, a radial tear of the medial meniscus was sutured by either PDS or LTS. Twelve sham-operated animals served as control. Half of the sheep were killed after 6 months, the other half after 12 months. The medial and lateral meniscus, synovial membrane, articular cartilage and ascendant lymph nodes up to the kidney were examined. Joint effusion was evaluated by MRI.
RESULTS: The synovial membrane was significantly thinner in the LTS group (6 months 85 +/- 10 microm, 1 year 100 +/- 28 microm) than in the PDS group (6 months 165 +/- 10 microm, 1 year 175 +/- 23 microm, P < 0.001) and the controls (6 months 150 +/- 17 microm, 12 months 192 +/- 21 microm, P < 0.001). The joint effusion was higher in the PDS than in the LTS group after 6 months, and tended to be higher in controls. In controls, effusion tended to be higher than in the LTS group. In all medial departments, osteoarthritis evolved much more intensely than in the lateral knee departments (P < 0.01). Bilateral lymph nodes from the groin up to the kidneys were larger (crosscut area) after 6 months in the controls (2.28 +/- 0.7 mm(2)) and PDS treated animals (2.3 +/- 0.7 mm(2)) than in the LTS group (1.3 +/- 0.3 mm(2), P < 0.001). After 1 year, node size differed significantly between controls and animals from the LTS group (1.98 +/- 0.4 mm(2) vs. 1.5 +/- 0.2 mm(2), P < 0.05), and between animals from the PDS and the LTS group (2.5 +/- 0.1 mm(2) vs. 1.5 +/- 0.2 mm(2), P < 0.001).
CONCLUSION: The polylactide thread LTS causes less immunological reaction and synovitis than a polydioxanone suture (PDS).
CLINICAL RELEVANCE: LTS may serve as an alternative to PDS for repair of slow healing structures such as tendons and menisci.
Christof Burger; Koroush Kabir; Christoph Rangger; Marcus Mueller; Thomas Minor; René H Tolba
Related Documents :
12718779 - Reconstruction of lip defects with the karapandzic technique.
9950529 - Tongue reconstruction: outcomes with the rectus abdominis flap.
18442689 - Comparison of clinical results according to amount of preserved remnant in arthroscopic...
8775119 - The use of cold therapy in the postoperative management of patients undergoing arthrosc...
8461959 - Grap repair: single-stage reconstruction of hypospadias as an out-patient procedure.
7924029 - A comparison between medial meniscus repair, partial meniscectomy, and normal meniscus ...
24465409 - Association between statin use and short-term outcome based on severity of ischemic str...
25173899 - Factors influencing the development and severity of dissociated vertical deviation in p...
25242099 - The course of prosthodontic patients' oral health-related quality of life over a period...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-08-08
Journal Detail:
Title:  Archives of orthopaedic and trauma surgery     Volume:  126     ISSN:  0936-8051     ISO Abbreviation:  Arch Orthop Trauma Surg     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-10-30     Completed Date:  2007-10-04     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  9011043     Medline TA:  Arch Orthop Trauma Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  695-705     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Absorbable Implants / adverse effects*
Inflammation / chemically induced*,  epidemiology*
Menisci, Tibial / injuries*,  surgery*
Polydioxanone / adverse effects*
Polyesters / adverse effects*
Reg. No./Substance:
0/Polyesters; 26969-66-4/poly(lactide); 31621-87-1/Polydioxanone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of low and high levels of moderate hypoxia on anaerobic energy release during supramaximal c...
Next Document:  The effect of bone tunnel dilation versus extraction drilling on the initial fixation strength of pr...