| Poly(lactic-co-glycolic acid) electrospun fibrous meshes for the controlled release of retinoic acid. | |
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MedLine Citation:
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PMID: 19683605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(lactic-co-glycolic acid) (PLGA) meshes loaded with retinoic acid (RA) were prepared by applying the electrospinning technique. The purpose of the present work was to combine the biological effects of RA and the advantages of electrospun meshes to enhancing the mass transfer features of controlled release systems and cell interaction with polymeric scaffolds. The processing conditions for the fabrication of three-dimensional meshes were optimized by studying their influence on mesh morphology. Tensile testing showed that RA loading influenced the meshes' mechanical properties by increasing their strength and rigidity. Moreover, the drug release and degradation profiles of the electrospun systems were compared to analogous RA-loaded PLGA films prepared by solvent casting. The results of this study highlight that the electrospun meshes preserved their fibrous structure after 4 months under in vitro physiological conditions and showed a sustained controlled release of the loaded agent in comparison to that observed for cast films. The bioactivity of the loaded RA was investigated on murine preosteoblasts cells by evaluating its influence on cell proliferation and morphology. |
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Authors:
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Dario Puppi; Anna Maria Piras; Nicola Detta; Dinuccio Dinucci; Federica Chiellini |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-14 |
Journal Detail:
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Title: Acta biomaterialia Volume: 6 ISSN: 1878-7568 ISO Abbreviation: Acta Biomater Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-05-31 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 101233144 Medline TA: Acta Biomater Country: England |
Other Details:
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Languages: eng Pagination: 1258-68 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cell Proliferation / drug effects Delayed-Action Preparations / metabolism* Electricity Glycolates / chemistry*, pharmacology Materials Testing / methods* Mice Microscopy, Confocal Microscopy, Electron, Scanning Molecular Weight Solutions Spectrophotometry, Ultraviolet Temperature Tensile Strength / drug effects Tissue Scaffolds / chemistry* Tretinoin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 0/Glycolates; 0/Solutions; 0/polylactic acid-polyglycolic acid copolymer; 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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