Document Detail

Polyketides from marine dinoflagellates of the genus Prorocentrum, biosynthetic origin and bioactivity of their okadaic acid analogues.
MedLine Citation:
PMID:  20105116     Owner:  NLM     Status:  MEDLINE    
Marine dinoflagellates of the genus Prorocentrum are famous for the production of okadaic acid (OA) and its analogues. This review covers first the source, chemistry and bioactivity of polyketides from Prorocentrum species. Then recent advances in the studies of biosynthetic origin of OA and its analogues are included. Moreover, the pharmacophore for the selective inhibition of OA to protein phosphatases types 1 (PP1) and 2A (PP2A) is highlighted.
Weimin Hu; Jing Xu; Jari Sinkkonen; Jun Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  10     ISSN:  1875-5607     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  51-61     Citation Subset:  IM    
Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, China.
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MeSH Terms
Catalytic Domain
Dinoflagellida / metabolism*
Enzyme Inhibitors / metabolism,  pharmacology
Macrolides / chemistry,  isolation & purification,  metabolism*,  pharmacology*
Marine Toxins / biosynthesis*,  chemistry,  isolation & purification,  pharmacology*
Okadaic Acid / analogs & derivatives*,  metabolism,  pharmacology*
Protein Binding
Protein Phosphatase 1 / antagonists & inhibitors,  chemistry,  physiology
Protein Phosphatase 2 / antagonists & inhibitors,  chemistry,  physiology
Species Specificity
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Macrolides; 0/Marine Toxins; 78111-17-8/Okadaic Acid; EC Phosphatase 1; EC Phosphatase 2

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