| Polyketides from marine dinoflagellates of the genus Prorocentrum, biosynthetic origin and bioactivity of their okadaic acid analogues. | |
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MedLine Citation:
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PMID: 20105116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Marine dinoflagellates of the genus Prorocentrum are famous for the production of okadaic acid (OA) and its analogues. This review covers first the source, chemistry and bioactivity of polyketides from Prorocentrum species. Then recent advances in the studies of biosynthetic origin of OA and its analogues are included. Moreover, the pharmacophore for the selective inhibition of OA to protein phosphatases types 1 (PP1) and 2A (PP2A) is highlighted. |
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Authors:
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Weimin Hu; Jing Xu; Jari Sinkkonen; Jun Wu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Mini reviews in medicinal chemistry Volume: 10 ISSN: 1875-5607 ISO Abbreviation: Mini Rev Med Chem Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-07-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101094212 Medline TA: Mini Rev Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 51-61 Citation Subset: IM |
Affiliation:
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Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catalytic Domain Dinoflagellida / metabolism* Enzyme Inhibitors / metabolism, pharmacology Humans Macrolides / chemistry, isolation & purification, metabolism*, pharmacology* Marine Toxins / biosynthesis*, chemistry, isolation & purification, pharmacology* Okadaic Acid / analogs & derivatives*, metabolism, pharmacology* Protein Binding Protein Phosphatase 1 / antagonists & inhibitors, chemistry, physiology Protein Phosphatase 2 / antagonists & inhibitors, chemistry, physiology Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Macrolides; 0/Marine Toxins; 78111-17-8/Okadaic Acid; EC 3.1.3.16/Protein Phosphatase 1; EC 3.1.3.16/Protein Phosphatase 2 |
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