| Polyisoprenoid, cholesterol and ubiquinone levels in human hepatocellular carcinomas. | |
| | |
MedLine Citation:
|
PMID: 2538136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The lipid composition of human hepatocellular carcinomas was examined. The level of dolichol in the tumours was decreased compared to control tissue, whereas the concentration of dolichyl phosphate did not exhibit any major change. A decrease in the amount of dolichyl ester was also observed. The pattern of individual polyisoprenoids in the free dolichol pool was changed in several carcinomas with a relative increase in the shorter dolichols. The isoprenol composition in the dolichyl ester and phosphate fractions of tumours were basically similar to those of controls. alpha-Unsaturated polyisoprenols are present in control livers at a level of 3% of the total free polyisoprenoid fraction, while this value was increased in the tumours. Similar to dolichol, the amount of ubiquinone was also decreased. The content of cholesterol was increased, while the fatty acid pattern of the dolichyl esters showed minor alterations. These modifications in lipid content indicate different mechanisms for the regulation of dolichol and dolichyl phosphate concentrations. The high levels of sterols in contrast to the low polyisoprenol content suggests interference with the regulation of the mevalonate pathway, which is the common biosynthetic route for cholesterol, ubiquinone and dolichol. |
| | |
Authors:
|
I Eggens; P G Elmberger; P Löw |
Related Documents
:
|
1175606 - Cholesterol 7alpha-hydroxylase. 2. biochemical properties and participation of endogeno... 16246556 - 4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent. 2513806 - Effect of 25-hydroxycholesterol and bile acids on the regulation of cholesterol metabol... 11751316 - Molecular organization of cholesterol in polyunsaturated membranes: microdomain formation. 2764916 - Isolation and sequencing of a cdna clone encoding acid phosphatase in rat liver lysosomes. 17043806 - Microbial transformation of ferulic acid to vanillic acid by streptomyces sannanensis m... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: British journal of experimental pathology Volume: 70 ISSN: 0007-1021 ISO Abbreviation: Br J Exp Pathol Publication Date: 1989 Feb |
Date Detail:
|
Created Date: 1989-05-05 Completed Date: 1989-05-05 Revised Date: 2012-05-07 |
Medline Journal Info:
|
Nlm Unique ID: 0372543 Medline TA: Br J Exp Pathol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 83-92 Citation Subset: IM |
Affiliation:
|
Division of Cellular and Neuropathology, Huddinge Hospital, Karolinska Institutet, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Carcinoma, Hepatocellular / analysis*, pathology Cholesterol / analysis* Dolichol / analysis* Dolichol Phosphates / analysis Fatty Acids / analysis Humans Liver Neoplasms / analysis*, pathology Middle Aged Ubiquinone / analysis* |
| Chemical | |
Reg. No./Substance:
|
0/Dolichol Phosphates; 0/Fatty Acids; 1339-63-5/Ubiquinone; 2067-66-5/Dolichol; 57-88-5/Cholesterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of surface electrode positioning on the compound action potential evoked by ulnar nerve stimu...
Next Document: A study of the photodegradation of leukotriene B4 by ultraviolet irradiation (UVB, UVA).