Document Detail


Polyhydroxylated sapphyrins: multisite non-metallic catalysts for activated phosphodiester hydrolysis.
MedLine Citation:
PMID:  16402829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Enhanced hydrolysis rates for the cleavage of bis(4-nitrophenyl)phosphate (BNPP), a model phosphodiester, may be achieved by using appropriately designed ditopic receptors containing the known phosphate-binding nucleus, sapphyrin, attached covalently to suitably oriented polyhydroxyl subunits. Evidence for the interaction between sapphyrin and BNPP comes from solid-state X-ray diffraction analysis of a diprotonated dihydroxylated sapphyrin-BNPP complex and from solution-phase (31)P NMR spectroscopic binding studies. The sapphyrins described in this paper may have a role to play as oligonucleotide cleavage agents.
Authors:
Vladimír Král; Kamil Lang; Jarmila Králová; Michal Dvorák; Pavel Martásek; Aileen O Chin; Andrei Andrievsky; Vincent Lynch; Jonathan L Sessler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  128     ISSN:  0002-7863     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-11     Completed Date:  2006-03-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  432-7     Citation Subset:  IM    
Affiliation:
Department of Analytical Chemistry, Institute of Chemical Technology, Prague, Czech Republic. kral@vscht.cz
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MeSH Terms
Descriptor/Qualifier:
Catalysis
Hydrogen Bonding
Hydrolysis
Hydroxylation
Kinetics
Molecular Structure
Nitrophenols / chemistry*
Porphyrins / chemistry*
X-Ray Diffraction
Chemical
Reg. No./Substance:
0/Nitrophenols; 0/Porphyrins; 0/sapphyrin; 645-15-8/bis(4-nitrophenyl)phosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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