| Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells. | |
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MedLine Citation:
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PMID: 20978772 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE(2), and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-protective agent in UV-induced skin damage. |
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Authors:
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Gennady Rosenblat; Shai Meretski; Joseph Segal; Mark Tarshis; Avi Schroeder; Alexandra Zanin-Zhorov; Gilead Lion; Arieh Ingber; Malka Hochberg |
Publication Detail:
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Type: Journal Article Date: 2010-10-27 |
Journal Detail:
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Title: Archives of dermatological research Volume: 303 ISSN: 1432-069X ISO Abbreviation: Arch. Dermatol. Res. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000462 Medline TA: Arch Dermatol Res Country: Germany |
Other Details:
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Languages: eng Pagination: 239-46 Citation Subset: IM |
Affiliation:
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Polyol Biotech Ltd, Granot Initiative Center, 38100, D.N. Hefer, Israel, gr.polyol@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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