| Poly(hydroxy acids) in drug delivery. | |
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MedLine Citation:
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PMID: 3549007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(hydroxy acids) so far have been examined for use in drug delivery in limited number, while the advantageous use of the polymers has been recognized due to their biodegradability and biocompatibility. Homo- and copolymers of lactic acid and glycolic acid have been studied in drug delivery by many workers, while homo- and copolymers of epsilon-caprolactone have been studied by only one group of workers. Although poly-hydroxybutyric acid had been found to be a naturally occurring polymer, examination as to the use of the polymer in drug delivery is rather recent and reports are still limited. In the present article, the use of poly(hydroxy acids) including homo- and copolymers of lactic acid and glycolic acid, polycaprolactone, and poly-beta-hydroxybutyric acid in drug delivery is reviewed. Physicochemical properties, biodegradability, and biocompatibility of the polymers, and evaluations in vitro and in vivo of specific dosage forms using the polymers, are included. The most recent work in our laboratories on the use of polyactic acid and poly-beta-hydroxybutyric acid is also included. |
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Authors:
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K Juni; M Nakano |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Critical reviews in therapeutic drug carrier systems Volume: 3 ISSN: 0743-4863 ISO Abbreviation: Crit Rev Ther Drug Carrier Syst Publication Date: 1987 |
Date Detail:
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Created Date: 1987-05-21 Completed Date: 1987-05-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8511159 Medline TA: Crit Rev Ther Drug Carrier Syst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 209-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biocompatible Materials Biodegradation, Environmental Chemical Phenomena Chemistry Chemistry, Physical Drug Administration Routes* Glycolates Hydroxy Acids / administration & dosage* Hydroxybutyrates Lactates Lactic Acid Lactones Physicochemical Phenomena Polyesters Polymers Pyrones Vehicles* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Glycolates; 0/Hydroxy Acids; 0/Hydroxybutyrates; 0/Lactates; 0/Lactones; 0/Polyesters; 0/Polymers; 0/Pyrones; 0/Vehicles; 24980-41-4/polycaprolactone; 26063-00-3/poly-beta-hydroxybutyrate; 50-21-5/Lactic Acid; 542-28-9/delta-valerolactone; 5579-78-2/epsilon-decalactone; 79-14-1/glycolic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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