Document Detail

Polyhedral microcalcifications at mammography: histologic correlation with calcium oxalate.
MedLine Citation:
PMID:  8430173     Owner:  NLM     Status:  MEDLINE    
Pathologists have associated calcium oxalate dihydrate (weddellite) in breast biopsy specimens with benign or borderline lesions and rarely with malignancy. These microcalcifications may have a polyhedral shape in histologic specimens owing to their crystalline structure. A retrospective radiologic-histologic correlation study was performed on 300 clusters of microcalcifications to determine if microcalcifications with a polyhedral shape could be found at mammography. In 19 cases (6.3%), polyhedral microcalcifications (PMs) were detected by two radiologists. In 12 of these 19 cases, weddellite crystals were found in the histologic specimen under polarized light; in seven cases, no calcification was found. Although rare, PMs can be found at mammography by radiologists aware of their existence. They are due to weddellite crystals and in this series were associated with benign disease in 89% of cases. Prospective studies are required to determine the frequency of PMs on screening mammograms and to evaluate their negative predictive value.
C Frouge; M Meunier; J M Guinebretière; R Gilles; D Vanel; G Contesso; R Di Paola; M Bléry
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiology     Volume:  186     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-03-11     Completed Date:  1993-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  681-4     Citation Subset:  AIM; IM    
Department of Radiology, Hôpital de Bicêtre, Kremlin Bicêtre, France.
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MeSH Terms
Breast / chemistry,  pathology*
Breast Diseases / epidemiology,  metabolism,  radiography*
Breast Neoplasms / chemistry,  epidemiology,  radiography*
Calcinosis / epidemiology,  metabolism,  radiography*
Calcium Oxalate / analysis*
Middle Aged
Retrospective Studies
Reg. No./Substance:
25454-23-3/Calcium Oxalate; 7236-42-2/weddellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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