Document Detail

Polyglycerophosphatide metabolism in Escherichia coli.
MedLine Citation:
PMID:  1095058     Owner:  NLM     Status:  MEDLINE    
When Escherichia coli B cells were labelled with [14-C] glycerol and chased, there was a marked sparing of the phosphatidyl moiety compared to the nonacylated glycerol moiety of phosphatidylglycerol. When energy-depleted cells were restored to an energy-rich medium there resulted a conversion of 32-P-labelled cardiolipin to phosphatidylglycerol, a lack of phosphatidic acid accumulation and no loss in total polyglycerophosphatide counts. In cell-free extracts, phosphatidic acid produced from 32-P-labelled cardiolipin by the action of Escherichia coli phosphalipase D, was readily recycled to form poly-glycerophosphatide. In the presence of glycerol, such extracts displayed traansphosphatidylase activity by degrading cardiolipin to phosphatidyglycerol mainly. The results as a whole indicate that the enzyme synthesizing cardiolipin together with cardiolipin-hydrolyzing phospholipase D constitute a cycle which is normally involved in the turnover of polyglycerophosphatides in Escherichia coli.
A Audet; R Cole; P Proulx
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  380     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-10-11     Completed Date:  1975-10-11     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  414-20     Citation Subset:  IM    
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MeSH Terms
Adenosine Triphosphate / pharmacology
Cardiolipins / metabolism
Escherichia coli / metabolism
Magnesium / pharmacology
Phosphatidic Acids / metabolism
Phosphatidylglycerols / metabolism*
Phospholipases / metabolism
Phospholipids / metabolism*
Reg. No./Substance:
0/Cardiolipins; 0/Phosphatidic Acids; 0/Phosphatidylglycerols; 0/Phospholipids; 56-65-5/Adenosine Triphosphate; 7439-95-4/Magnesium; EC 3.1.-/Phospholipases

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